实用心脑肺血管病杂志2026，Vol.34Issue(9)：28-33,6.DOI:10.12114/j.issn.1008-5971.2026.00.203
Toll样受体基因多态性及其相乘交互效应与儿童反复肺炎的关联研究
Association of Toll-Like Receptor Gene Polymorphisms and Their Multiplicative Interaction Effects with Recurrent Pneumonia in Children
摘要
Abstract
Objective To investigate the association of Toll-like receptor(TLR)gene polymorphisms and their multiplicative interaction effects with recurrent pneumonia(RP)in children.Methods In this study,a prospective controlled study design was used to select 99 children with community-acquired pneumonia(CAP)who were diagnosed and treated in the Department of Pediatrics,Suzhou Municipal Hospital from January 2022 to June 2024 as the study subjects.The general data of the children were collected,and the TLR gene polymorphism(genotype and allele frequency of TLR2 gene rs1898830 and rs5743708 locus,TLR3 gene rs3775291 and rs5752024 locus,TLR4 gene rs4986790 and rs5030728 locus)was detected.The children were followed up for a total of 12 months,and the endpoint event was RP.According to the occurrence of RP,the children were divided into the recurrence group and the control group.Multivariate Logistic regression analysis was used to explore the association of TLR gene single nucleotide polymorphism(SNP)locus polymorphism and their multiplicative interaction effects with RP in children.Results Among the 99 children,49(49.5%)developed RP.There were significant differences in genotype distribution and allele frequency of TLR2 gene rs1898830 and rs5743708 locus,TLR3 gene rs5752024 locus and TLR4 gene rs5030728 locus between the two groups(P<0.05).Multivariate Logistic regression analysis showed that when the interaction term was not included,the G allele of TLR2 gene rs1898830 locus,the C allele of TLR2 gene rs5743708 locus,the A allele of TLR3 gene rs3775291 locus,the A allele of TLR4 gene rs4986790 locus,the G allele of TLR3 gene rs5752024 locus and the C allele of TLR4 gene rs5030728 locus were independently associated with the risk of RP in children(P<0.05);after the interaction term was included,there was a multiplicative interaction between the TLR2 gene rs1898830 locus and the TLR2 gene rs5743708 locus,between the TLR3 gene rs3775291 locus and the TLR4 gene rs4986790 locus,between the TLR3 gene rs5752024 locus and the TLR4 gene rs5030728 locus(Pinteraction<0.05).Conclusion Carrying TLR2 gene rs1898830 locus G allele,TLR2 gene rs5743708 locus C allele,TLR3 gene rs3775291 locus A allele,TLR4 gene rs4986790 locus A allele,TLR3 gene rs5752024 locus G allele,TLR4 gene rs5030728 locus C allele are independently associated with RP risk in children.There are multiplicative interaction effects between TLR2 gene rs1898830 locus and TLR2 gene rs5743708 locus,TLR3 gene rs3775291 locus and TLR4 gene rs4986790 locus,TLR3 gene rs5752024 locus and TLR4 gene rs5030728 locus.关键词
肺炎/反复肺炎/儿童/Toll样受体/多态性,单核苷酸/相乘交互效应Key words
Pneumonia/Recurrent pneumonia/Child/Toll-like receptors/Polymorphism,single nucleotide/Multiplicative interaction effect分类
医药卫生引用本文复制引用
李世芹,赵玉龙..Toll样受体基因多态性及其相乘交互效应与儿童反复肺炎的关联研究[J].实用心脑肺血管病杂志,2026,34(9):28-33,6.基金项目
江苏省卫生健康委员会科研项目(M2022058) （M2022058）
