实用医学杂志2026，Vol.42Issue(15)：2684-2691,8.DOI:10.3969/j.issn.1006-5725.2026.15.002
时空针灸灵龟八法指导艾灸对缺血性脑卒中后睡眠障碍患者5-羟色胺及睡眠质量的影响
Effects of acupuncture of time acupoint space based on Linggui Bafa on serum 5-hydroxytryptamine and sleep quality in patients with sleep disorders following ischemic stroke
摘要
Abstract
Objective To investigate the clinical efficacy of acupuncture of time acupoint space based on Linggui Bafa in patients with sleep disorders secondary to ischemic stroke,and to evaluate its effects on serum 5-hydroxytryptamine(5-HT)and melatonin(MT)levels,neurological function,and emotional status.Methods A total of 78 patients with ischemic stroke and concurrent sleep disorders treated at our hospital between June 2024 and June 2025 were prospectively enrolled and randomly divided into a control group and a treatment group(n=39 each).The control group received conventional treatment and sleep management for ischemic stroke.The treat-ment group received the same conventional therapy plus Linggui Bafa-based spatiotemporal acupoint selection moxi-bustion.Both groups received continuous treatment for 3 weeks.The overall clinical efficacy,scores on the Fatigue Severity Scale(FSS),Pittsburgh Sleep Quality Index(PSQI),Hospital Anxiety and Depression Scale(HADS),and National Institutes of Health Stroke Scale(NIHSS),as well as serum 5-HT and MT levels,were compared between the two groups.Adverse events during the treatment period were also recorded.Results The overall effective rate in the treatment group was significantly higher than that in the control group(P＜0.05).Repeated-measures analysis of variance(ANOVA)revealed significant main effects of time and group,as well as significant time × group interaction effects,on the FSS,PSQI,HADS,and NIHSS scores,and on serum 5-HT and MT levels(all P＜0.05).Further simple main effect analysis demonstrated that after 3 weeks of treatment,the scores on all aforementioned scales in the treatment group were significantly lower than those in the control group,whereas serum 5-HT and MT levels were significantly higher(all P＜0.05).No significant difference in the inci-dence of adverse events was observed between the two groups(P＞0.05).Conclusions As an adjunct to conven-tional therapy,Linggui Bafa-based spatiotemporal moxibustion can effectively improve sleep quality,alleviate fa-tigue,anxiety,and depression,and promote neurological recovery in patients with sleep disorders following ischemic stroke.The underlying mechanism may be related to the regulation of sleep-associated neurotransmitters,such as 5-HT and MT.The intervention demonstrates a favorable safety profile and holds promise for clinical application.关键词
时空针灸灵龟八法/艾灸/缺血性脑卒中/睡眠障碍/5-羟色胺/褪黑素Key words
Linggui Bafa/moxibustion/ischemic stroke/sleep disorder/5-hydroxytryptamine/melatonin分类
医药卫生引用本文复制引用
刘亮先,李莉,韩丽红,和智娟,王祖红,黄培冬,盘雪娇..时空针灸灵龟八法指导艾灸对缺血性脑卒中后睡眠障碍患者5-羟色胺及睡眠质量的影响[J].实用医学杂志,2026,42(15):2684-2691,8.基金项目
国家自然科学基金地区项目(编号:82360977) （编号:82360977）
云南省科技厅科技计划项目(编号:202101AZ070001-089,202301AZ070001-155) （编号:202101AZ070001-089,202301AZ070001-155）
