实用医学杂志2026，Vol.42Issue(15)：2722-2729,8.DOI:10.3969/j.issn.1006-5725.2026.15.007
血小板来源PD-L1在肿瘤血行转移中的免疫抑制效应及其靶向治疗策略
Immunosuppressive effects and targeted therapeutic strategies of platelet-derived PD-L1 in hematogenous tumor metastasis
摘要
Abstract
Platelets are the second most abundant cellular component in blood after erythrocytes and have traditionally been recognized primarily for their roles in hemostasis and thrombosis.The expression of programmed death-ligand 1(PD-L1)on the platelet surface enables direct inhibition of T cell function.Moreover,platelets can form a physical barrier by surrounding circulating tumor cells(CTCs),thereby amplifying immunosuppressive sig-nals synergistically and establishing a mobile immune barrier during hematogenous tumor metastasis.This review systematically summarizes the origin and regulatory mechanisms of platelet PD-L1(pPD-L1)and proposes a triple-inhibition model of immune evasion mediated by pPD-L1.Furthermore,it highlights the critical role of pPD-L1 as a liquid biopsy biomarker in reversing resistance to immune checkpoint inhibitors(ICIs)and suppressing hematog-enous tumor metastasis,providing a theoretical basis for precision therapies targeting pPD-L1.关键词
血小板/程序性死亡配体1/免疫逃逸/血行转移/免疫检查点抑制剂/抗血小板治疗Key words
platelets/programmed death-ligand 1/immune evasion/hematogenous metastasis/immune checkpoint inhibitors(ICIs)/antiplatelet therapy分类
医药卫生引用本文复制引用
姜佳宬,马洁,朱伟..血小板来源PD-L1在肿瘤血行转移中的免疫抑制效应及其靶向治疗策略[J].实用医学杂志,2026,42(15):2722-2729,8.基金项目
国家自然科学基金资助项目(编号:32270964) （编号:32270964）
