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中药紫苏根质量标准的研究

杨铭轩 贾晓蕊 王向东 李先宽 柴欣 王跃飞 钱桂英 杨静

时珍国医国药2026，Vol.37Issue(15)：2863-2867,5.
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时珍国医国药2026，Vol.37Issue(15)：2863-2867,5.DOI:10.70976/j.1008-0805.SZGYGY-2026-1510

中药紫苏根质量标准的研究

Study on the quality standard of Chinese medicinal Radix Perillae

杨铭轩 1贾晓蕊 1王向东 2李先宽 3柴欣 4王跃飞 4钱桂英 5杨静4

作者信息

  • 1. 天津中医药大学中医药研究院,现代中药创制全国重点实验室,天津市中药化学与分析重点实验室,天津 301617
  • 2. 现代中医药海河实验室,天津 301617
  • 3. 天津中医药大学中药学院,天津 301617
  • 4. 天津中医药大学中医药研究院,现代中药创制全国重点实验室,天津市中药化学与分析重点实验室,天津 301617||现代中医药海河实验室,天津 301617
  • 5. 常熟市中医院(新区医院),江苏 常熟 215500
  • 折叠

摘要

Abstract

Objective To establish a quality standard for slices of Radix Perillae and provide a scientific basis for its standardized appli-cation.Methods Fifteen batches of Radix Perillae slices from different sources were studied.Using rosmarinic acid as the indicator com-ponent,qualitative identification was conducted by thin-layer chromatography(TLC),and its content was quantified by high-performance liquid chromatography(HPLC).Routine tests including moisture,total ash,acid-insoluble ash,and extractives were per-formed according to the methods specified in Chinese Pharmacopoeia(中国药典).Results TLC analysis showed that 13 batches(except ZSG0001 and ZSG0009)exhibited clear blue fluorescent spots corresponding to the rosmarinic acid reference,with good resolu-tion.The results of the routine tests were:moisture,7.4%-10.4%(proposed limit:≤11.0%);total ash,2.0%-4.6%(proposed limit:≤5.0%);acid-insoluble ash,below 0.50%in all samples(no limit specified);extractives,6.0%-9.0%(proposed limit:≥5.0%).All batches complied with the proposed criteria for these items.The content of rosmarinic acid determined by HPLC ranged from 0.044%to 0.384%,with a mean value of 0.135%.Based on these results,a content limit of not less than(≥)0.05%was pro-posed,which was met by 13 batches(excluding ZSG0001 and ZSG0009).Conclusion A comprehensive quality evaluation system encompassing physicochemical tests,TLC identification,and content determination was established for Radix Perillae slices through analysis of 15 batches from different sources.This system complements existing local standards by providing more comprehensive indica-tors,thereby enabling effective quality control,ensuring clinical safety and efficacy,and offering technical support for the standardized cultivation,processing,and medicinal use of this herb.

关键词

紫苏根/薄层鉴别/高效液相色谱/迷迭香酸

Key words

Radix Perillae/TLC identification/HPLC/Rosmarinic acid

分类

医药卫生

引用本文复制引用

杨铭轩,贾晓蕊,王向东,李先宽,柴欣,王跃飞,钱桂英,杨静..中药紫苏根质量标准的研究[J].时珍国医国药,2026,37(15):2863-2867,5.

基金项目

天津市科技计划项目(24ZYJDSS00300) （24ZYJDSS00300）

苏州市科技计划项目(SKY2021019) （SKY2021019）

常熟市卫生健康委员会科技计划项目(CSWS202120) （CSWS202120）

时珍国医国药

1008-0805

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