临床医学工程2026，Vol.33Issue(7)：769-773,5.DOI:10.3969/j.issn.1674-4659.2026.07.0769
重复经颅磁刺激联合乌灵胶囊治疗脑梗死后抑郁伴失眠的效果
Efficacy of Repetitive Transcranial Magnetic Stimulation Combined with Wul-ing Capsule in the Treatment of Post-Stroke Depression Complicated by In-somnia
摘要
Abstract
Objective To investigate the efficacy of repetitive transcranial magnetic stimulation(rTMS)combined with Wuling Capsule in the treatment of post-stroke depression complicated by insomnia.Methods A total of 70 patients with post-stroke depression complicated by insomnia admitted to our hospital from October 2023 to March 2024 were selected as subjects and divided into the control group and the study group using a random number table method.The control group was treated with Wuling Capsule,while the study group was treated with Wuling Capsule combined with rTMS.The clinical efficacy,neurotransmitter levels,emotional and sleep indicators,imaging indicators,and adverse reactions were compared between the two groups.Results The total effective rate of the study group was significantly higher than that of the control group(P＜0.05).Compared with pre-treatment,the levels of 5-HT,DA,and NE increased in both groups after treatment,and the levels of 5-HT,DA,and NE after treatment in the study group were significantly higher than those in the control group(P＜0.05).Compared with pre-treatment,the HAMD-17 and PSQI scores decreased and sleep efficiency improved in both groups after treatment,with greater changes in the study group than in the control group(P＜0.05).Compared with pre-treatment,the blood flow velocities of the left middle cerebral artery,left anterior cerebral artery,and basilar artery increased in both groups after treatment,and those in the study group were significantly higher than those in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions rTMS combined with Wuling Capsule has significant efficacy in the treatment of post-stroke depression complicated by insomnia.Its synergistic mechanism is related to the multi-level complementary effects of up-regulation of monoamine neurotransmitters,improvement of cerebral perfusion and remodeling of sleep structure,with a favorable safety profile.关键词
重复经颅磁刺激/乌灵胶囊/脑梗死后抑郁/失眠Key words
Repetitive transcranial magnetic stimulation/Wuling Capsule/Post-stroke depression/Insomnia分类
医药卫生引用本文复制引用
王裕鹏,段智慧,王会林,刘瑞华,黄超..重复经颅磁刺激联合乌灵胶囊治疗脑梗死后抑郁伴失眠的效果[J].临床医学工程,2026,33(7):769-773,5.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20220946) （LHGJ20220946）
