临床医学工程2026，Vol.33Issue(7)：795-799,5.DOI:10.3969/j.issn.1674-4659.2026.07.0795
较高剂量连续性肾脏替代治疗对脓毒症合并急性肾损伤患者疗效及安全性的影响
Impact of Higher-Dose Continuous Renal Replacement Therapy on Efficacy and Safety in Patients with Sepsis Complicated by Acute Kidney Injury
摘要
Abstract
Objective To investigate the impact of higher-dose continuous renal replacement therapy(CRRT)on the efficacy and safety in patients with sepsis complicated by acute kidney injury(AKI).Methods A total of 60 patients with sepsis complicated by AKI admitted to the ICU of Yantian District People's Hospital of Shenzhen from September 2021 to October 2024 were enrolled and divided into the observation group and the control group using the random number table,with 30 cases in each group.Both groups received conventional treatment.The control group was given standard-dose CRRT at 20～25 mL·kg-1·h-1,while the observation group was given higher-dose CRRT at 30～35 mL·kg-1·h-1.The clinical efficacy,renal function,hemodynamics,inflammatory factor levels and incidence of adverse events were compared between the two groups.Results The time to urine output recovery and ICU length of stay in the observation group were significantly shorter than those in the control group(P＜0.05).There was no statistically significant difference in the proportion of ongoing renal replacement therapy,28-day mortality rate,duration of mechanical ventilation,Sequential Organ Failure Assessment(SOFA)score and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score between the two groups(P＞0.05).After treatment,the levels of serum creatinine(Scr),blood urea nitrogen(BUN),procalcitonin(PCT)and C-reactive protein(CRP)in both groups significantly decreased compared with pre-treatment(P＜0.05),but there was no statistically significant difference between the two groups(P＞0.05).There was no significant difference in the use of vasoactive drugs and mean arterial pressure(MAP)between the two groups(P＞0.05).There was no statistically significant difference in the incidence of adverse events between the two groups(P＞0.05).Conclusions Higher-dose CRRT at 30～35 mL·kg-1·h-1 can significantly shorten the time to renal function recovery and ICU length of stay in patients with sepsis complicated by AKI,without significantly increasing the incidence of serious adverse events.关键词
较高剂量/连续性肾脏替代治疗/脓毒症/急性肾损伤/疗效/安全性Key words
Higher-dose/Continuous renal replacement therapy/Sepsis/Acute kidney injury/Efficacy/Safety分类
医药卫生引用本文复制引用
荆璐,刘晅,黄建鑫..较高剂量连续性肾脏替代治疗对脓毒症合并急性肾损伤患者疗效及安全性的影响[J].临床医学工程,2026,33(7):795-799,5.基金项目
深圳市盐田区医疗卫生科技创新项目(项目编号:YTWS20200206) （项目编号:YTWS20200206）
