医药导报2026，Vol.45Issue(8)：1370-1376,7.DOI:10.3870/j.issn.1004-0781.2026.08.010
线粒体功能受损参与类风湿关节炎病理机制及调控线粒体功能药物的研究进展
Advance in the Study of Mitochondrial Dysfunction in the Pathogenesis of Rheumatoid Arthritis and Drugs Targeting Mitochondrial Function
摘要
Abstract
Mitochondria,known as the"powerhouse"of the cell,plays a vital role not only in cellular metabolism but also as an important intracellular signaling hub.Rheumatoid arthritis(RA)is an inflammatory autoimmune disease with high in-cidence and complex etiology.Mitochondrial dysfunction not only impairs the normal function of immune cells but may also lead to alterations in various forms of cell death,such as apoptosis and autophagy.In RA patients,mitochondrial dysfunction plays a sig-nificant role in the pathological mechanisms of the disease,and restoring mitochondrial function may represent a potential thera-peutic strategy for RA.This article reviewed the molecular mechanisms by which mitochondrial dysfunction participates in the pathological process of RA,as well as the drugs that exert therapeutic effects by regulating mitochondrial activity,aiming to pro-vide new insights and strategies for further understanding the pathogenesis of RA and for the development of RA therapeutics.关键词
抗风湿药物/类风湿关节炎/线粒体损伤/滑膜炎症Key words
Anti-rheumatic drugs/Rheumatoid arthritis/Mitochondrial dysfunction/Synovitis分类
医药卫生引用本文复制引用
王涵,张玲玲..线粒体功能受损参与类风湿关节炎病理机制及调控线粒体功能药物的研究进展[J].医药导报,2026,45(8):1370-1376,7.基金项目
国家自然科学基金资助项目(82373878,U1803129) （82373878,U1803129）
安徽省自然科学基金面上项目(2308085MH312) （2308085MH312）
安徽省教育厅重大项目(2023AH040080) （2023AH040080）
安徽转化医学研究院研究基金资助项目(2024zh-08). （2024zh-08）
