中草药2026，Vol.57Issue(15)：5789-5798,10.DOI:10.7501/j.issn.0253-2670.2026.15.001
山楝枝叶中1个新的半日花烷型二萜
A new labdane-type diterpenoid from branches and leaves of Aphanamixis polystachya
摘要
Abstract
Objective To study chemical constituents and neuroprotective activities of the branches and leaves of Aphanamixis polystachya.Methods Monomer compounds were obtained through separation and purification using various chromatographic techniques including silica gel column chromatography,reversed-phase ODS column,Sephadex LH-20,semi-preparative HPLC,and recrystallization.Their structures were elucidated by modern spectroscopic methods including nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HRESIMS),infrared spectroscopy(IR),ultraviolet spectroscopy(UV),and single-crystal X-ray diffraction analysis.Results A total of 21 compounds were isolated from the branches and leaves of A.polystachya,identified as,(2R,5R,8S,9S,10R)-1-[(E)-5-hydroxy-3-methylpent-3-en-1-yl]-4,4,8,10-tetramethyldecahydronaphthalene-2,8-diol(1),(1S,4aS,7R,8R,8aS)-decahydro-8-[(3E)-5-hydroxy-3-methyl-3-penten-1-yl]-4,4,7,8a-tetramethyl-1,7-naphthalenediol(2),3β,8α,15-trihydroxy-13-labdane(3),8β,15-dihydroxy-ent-labda-13E-en-3-one(4),labd-13(E)-ene-8α,15-diol(5),labd-13(E)-ene-8α-hydroxy-15-acetate(6),labda-7,13E-dien-15-ol(7),labda-8,13E-dien-15-ol(8),brachytylin D(9),labda-8(17),13E-dien-15-ol(10),selin-11-en-4α-ol(11),(±)-selin-11-en-4α-ol(12),(1S,5R,9R)-10,10-dimethyl-2,6-dimethylenebicyclo[7.2.0]undecane-5-ol(13),caryophyllenol-Ⅱ(14),ciwujiatone(15),lyoniresinol(16),isolariciresinol(17),(±)-ficusesquilignan A(18),ficusesquilignan B(19),syringaresinol(20),methyl rosmarinate(21).Conclusion Compound 1 is a novel compound designated as labdane diterpenoid Z.Compounds 2-4,9,11-15,and 18-21 are isolated from genus Aphanamixis for the first time,which further enriches the chemical component database of the genus Aphanamixis.Furthermore,biological activity assays reveals that compound 21 exhibits neuroprotective activity.关键词
山楝枝叶/半日花烷型二萜Z/迷迭香酸甲酯/石竹烯醇-Ⅱ/刺五加酮/神经保护活性Key words
branches and leaves of Aphanamixis polystachya(Wall.)R.N.Parker/labdane diterpenoid Z/methyl rosmarinate/caryophyllenol-Ⅱ/ciwujiatone/neuroprotective activity分类
医药卫生引用本文复制引用
孙出香,蒲婉君,李金玉,刘翰飞,张妮,潘卫东..山楝枝叶中1个新的半日花烷型二萜[J].中草药,2026,57(15):5789-5798,10.基金项目
国家自然科学基金项目(32160102) （32160102）
