中草药2026，Vol.57Issue(15)：5799-5805,7.DOI:10.7501/j.issn.0253-2670.2026.15.002
裸花紫珠中1个新的单萜类化合物及其抗MRSA活性评价
A new monoterpene from Callicarpa nudiflora and its anti-MRSA activity
摘要
Abstract
Objective To study the chemical constituents of the dried leaves of Callicarpa nudiflora and discover bioactive compounds with anti-methicillin-resistance Staphylococcus aureus(MRSA)effects.Methods A systematic separation of chemical constituents was conducted by comprehensive chromatographic methods,including silica gel,Sephadex LH-20,ODS column chromatography and other chromatographic techniques.The structures of the isolated compounds were determined on the basis of spectroscopic analysis including IR,HR-ESI-MS,1H-NMR,13C-NMR,HSQC,HMBC,COSY,etc.The minimum inhibitory concentrations(MICs)of the compounds against Staphylococcus aureus,MRSA,Escherichia coli,and multidrug-resistant E.coli were determined by the nutrient broth dilution method.Results One monoterpene,named(Z)-2-methyl-6-methyleneocta-2,7-dine-1-yl(E)-3-(4-hydroxyphenyl)acrylate(1),and four sesquiterpenoids,named monasuslunin(2),(1S,5R,9R)-10,10-dimethyl-2,6-dimethylenebicyclo[7.2.0]undecan-5-ol(3),7-epi-eudesm-4(15)-ene-1β,6β-diol(4),sclareolide(5)were isolated and identified.Compound 1 exhibited strong inhibitory effects against S.aureus 29213 and MRSA T144,with MICs of 8 μg/mL for both.The MICs against E.coli 25922 and E.coli B2 were both greater than 8 μg/mL.Conclusion Compound 1 is a new compound named Callinuene A and compounds 3-5 are first isolated within this species.Compound 1 exhibits significant anti-MRSA activity.关键词
裸花紫珠/单萜类化合物/倍半萜类化合物/(Z)-2-甲基-6-亚甲基辛-2,7-二烯-1-基(E)-3-(4-羟基苯基)丙烯酸酯/紫珠烯A/7-表-桉叶-4(15)-烯-1β,6β-二醇/香紫苏内酯/抗MRSA活性Key words
Callicarpa nudiflora Hook.et Arn/monoterpene/sesquiterpenoids/(Z)-2-methyl-6-methyleneocta-2,7-dine-1-yl(E)-3-(4-hydroxyphenyl)acrylate/callinuene A/7-epi-eudesrn-4(15)-ene-1β,6β-diol/sclareolide/anti-MRSA activity分类
医药卫生引用本文复制引用
唐宇,陈昊,王建斌..裸花紫珠中1个新的单萜类化合物及其抗MRSA活性评价[J].中草药,2026,57(15):5799-5805,7.基金项目
国家自然科学基金资助项目(81903481) （81903481）
江苏省研究生科研创新计划(KYCX24_3844) （KYCX24_3844）
扬州大学2025年大学生创新创业训练计划项目(XCX20250849) （XCX20250849）
