中草药2026，Vol.57Issue(15)：5806-5813,8.DOI:10.7501/j.issn.0253-2670.2026.15.003
裕丹参中1个新水溶性酚酸
A new water-soluble phenolic acid from Salvia miltiorrhiza
摘要
Abstract
Objective To study the chemical constituents of Salvia miltiorrhiza and their anti-asthma activity.Methods The compounds were isolated and purified by silica gel column chromatography,gel column chromatography and preparative liquid chromatography.Their structures were identified based on spectroscopic data and physicochemical properties.The anti-asthma activity of the obtained compounds was evaluated using β-hexosaminidase release assay and RBL-2H3 cell degranulation model.Results Seven compounds were isolated from the ethyl acetate fraction of S.miltiorrhiza and identified as(SS)-3-(3-hydroxy-4-methoxyphenyl)-1-methoxy-1-oxopropan-2-yl(2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((S)-3-(3,4-dihydroxyphenyl)-1-ethoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate(1),rosmarinic acid(2),methyl linoleate(3),4-oxononanoic acid(4),(Z)-9-octadecenoic acid(5),(9Z,12Z)-nonadeca-9,12-dienoic acid(6),and n-13,16-nonadecadienoic acid(7).The bioactivity results showed that compound 1 inhibited the release of β-hexosaminidase,reduced the levels of mouse mast cell protease-1(mMCP-1),β-mast cell tryptase(β-MCT),histamine(HIS)and leukotriene C4(LTC4),and significantly ameliorated the degranulation of RBL-2H3 cells.Conclusion Compound 1 is a new water-soluble phenolic acid,named 9(''')-ethyl salvianolate B,that may exert anti-asthma effect by inhibiting mast cell degranulation.关键词
裕丹参/9(''')-丹酚酸B单乙酯/迷迭香酸/亚油酸甲酯/水溶性酚酸/抗哮喘Key words
Salvia miltiorrhiza Bunge/9(''')-ethyl salvianolate B/rosmarinic acid/methyl linoleate/water-soluble phenolic acid/anti-asthma分类
医药卫生引用本文复制引用
任英杰,曾梦楠,张明亮,陈小菲,郑晓珂,唐进法,任献青,冯卫生..裕丹参中1个新水溶性酚酸[J].中草药,2026,57(15):5806-5813,8.基金项目
国家自然科学基金资助项目(82505008) （82505008）
河南省自然科学基金(252300421631) （252300421631）
河南省卫生健康委员会国家中医药传承创新中心联合共建科研专项(2024ZXZX1185) （2024ZXZX1185）
河南省中医药科研专项(2025ZY3007) （2025ZY3007）
河南省博士后科研项目资助(HN2026087) （HN2026087）
河南中医药大学第一附属医院博士科研启动基金(2023BSJJ030) （2023BSJJ030）
