中草药2026，Vol.57Issue(15)：5837-5847,11.DOI:10.7501/j.issn.0253-2670.2026.15.006
基于成分状态定量模型分析丹参-苦参配伍过程中丹酚酸B-苦参碱的酸碱复合反应规律
Analysis of acid-base complexation reaction patterns of salvianolic acid B and matrine during compatibility of Salviae Miltiorrhizae Radix et Rhizoma and Sophorae Flavescentis Radix based on quantitative model of component states
摘要
Abstract
Objective Based on a confined mass transfer mathematical model,this study aims to establish a quantitative analysis method for the existing states of matrine in the complex solution environment of traditional Chinese medicine(TCM),and elucidate the influence pattern of the compatibility ratio of Danshen(Salviae Miltiorrhizae Radix et Rhizoma,SMRR)and Kushen(Sophorae Flavescentis Radix,SFR)on its acid-base complexation reaction.Methods Based on the mass transfer differences of component states during nanofiltration(NF)and ultrafiltration(UF),the mass transfer coefficient of matrine was fitted taking the component transmission rate and membrane flux as evaluation indicators.Using the molecular and ionic monomer components as references,a quantitative calculation model for the existing states was constructed.The existing states of matrine in the SFR extract and the SMRR-SFR co-extract were fitted to analyze the occurrence patterns of acid-base complexation reactions under different solution environments.Results Coupling UF and NF enhanced the separation differences between the ionic and molecular states of matrine,thereby improving the accuracy of the quantitative calculation model for the ionic state.The correlation coefficients of the power function equations for quantitatively calculating the existing states of matrine were all greater than 0.97,indicating that the model was successfully established.The proportion of matrine in the molecular state was approximately 1.21％—1.91％in both the SFR extract and the co-extract.In the SFR extract,matrine existed as 36.90％in the ionic state and 61.98％in the associated state.After compatibility and extraction of SFR and SMRR,the existing form of matrine changed significantly.When the compatibility ratio of SMRR was low,the ionic state was dominant,with the increase in the proportion of SMRR,the ionic proportion of matrine gradually decreased from 66.73％to 45.83％,transforming into a complex-structured composite state,and the corresponding composite state proportion rose from 31.87％to 52.90％.Conclusion A quantitative calculation method for the existing states of matrine in different solution environments was successfully constructed,providing technical support for elucidating the states of components in complex solution environments.关键词
限域传质数学模型/存在状态/苦参碱/丹酚酸B/丹参/苦参/制剂配伍/纳滤/超滤/动态光散射法/扫描电子显微镜分类
医药卫生引用本文复制引用
邢丹彤,张子涵,于炅鹭,支兴蕾,董政起,李存玉..基于成分状态定量模型分析丹参-苦参配伍过程中丹酚酸B-苦参碱的酸碱复合反应规律[J].中草药,2026,57(15):5837-5847,11.基金项目
国家自然科学基金项目(82274106) （82274106）
中药制药过程控制与智能制造技术全国重点实验室创新项目(NZYSKL240207) （NZYSKL240207）
2026年度南京中医药大学"揭榜挂帅"重大项目 （）
