癫痫动物模型的选择与应用
Selection and application of epilepsy animal models
摘要
Abstract
This review aims to address the clinical challenges of unclear pathogenesis of epilepsy and the fact that drug-resistant epilepsy accounts for up to 30%,as well as to provide a reliable tool for epilepsy research and new drug development.Three core aspects of epilepsy animal models are summarized:classification,establishment method,and evaluation systems.Models were classified from multiple perspectives,including seizure frequency,age group,and criteria of the International League Against Epilepsy,and corresponding application scenarios were analyzed.The technical characteristics,advantages,and disadvantages of in vitro and in vivo models(including chemical,physical,and gene editing approaches)are reviewed.Behavioral analysis was found to serve as the foundation for evaluation,supplemented by electroencephalogram detection and histological verification to further exclude false positives and ensure model accuracy and effectiveness.Additionally,key challenges are identified and discussed,such as species-specific pathological differences,insufficient drug resistance simulation,and difficulties in constructing comorbidity models.The findings provide comprehensive references for model selection,assisting researchers in accurately matching animal models with their research objective and experimental conditions,improving research efficiency,and promoting the in-depth development of epilepsy mechanism research and clinical translation.关键词
癫痫动物模型/模型选择/建模方法/模型评估Key words
epilepsy animal model/model selection/model establishment methods/model evaluation分类
生物科学引用本文复制引用
李嘉琦,王佳颖,陈紫萱,宋晶晶,王飞越,韩帅,马月宏..癫痫动物模型的选择与应用[J].中国实验动物学报,2026,34(7):1017-1035,19.基金项目
国家自然科学基金(82460819),内蒙古自治区自然科学基金(2024LHMS08029),内蒙古自治区"英才兴蒙"工程蒙药抗肝纤维化研究团队项目(2026TEL30),内蒙古自治区重点研发和成果转化计划项目,内蒙古医科大学致远人才项目治学人才(ZY20241201),内蒙古人才开发基金(22056),内蒙古医科大学蒙药抗肝纤维化作用研究科技创新团队(YKD2022TD039),内蒙古医科大学本科教育教学改革研究与实践项目(NYJXGGSJ2024044),内蒙古医科大学思想政治工作精品培育项目(NYD2025SZJP014),内蒙古医科大学英才培育项目(YCPY2026069). Funded by National Natural Science Foundation of China(82460819),Inner Mongolia Natural Science Foundation(2024LHMS08029),Yingcai Xingmeng Program of Inner Mongolia Autonomous Region:Research Team Project on Anti-Hepatic Fibrosis of Traditional Mongolian Medicine(2026TEL30),Key Research and Development and Achievement Transformation Program of Inner Mongolia Autonomous Region,Inner Mongolia Medical University Zhiyuan Talent Program-Academic Talents(ZY20241201),Inner Mongolia Talent Development Fund(22056),Scientific and Technological Innovation Team for Research on Anti-Hepatic Fibrosis Effect of Mongolian Medicine,Inner Mongolia Medical University(YKD2022TD039),Research and Practice Project of Undergraduate Education and Teaching Reform,Inner Mongolia Medical University(NYJXGGSJ2024044),High-Quality Cultivation Project for Ideological and Political Work,Inner Mongolia Medical University(NYD2025SZJP014),Elite Cultivation Project of Inner Mongolia Medical University(YCPY2026069). （82460819）
