中国实验动物学报2026，Vol.34Issue(7)：1036-1048,13.DOI:10.3969/j.issn.1005-4847.2026.07.009
乳腺癌动物模型的构建方法及针刺干预效应研究现状
Breast cancer animal model establishment methods and the effects of acupuncture intervention
摘要
Abstract
Breast cancer is one of the most common and life-threatening malignant tumors among females worldwide,with an increasing annual incidence.Although various treatments are available,issues such as postoperative recurrence,metastasis,and treatment-related side effects continue to significantly impact patient quality of life.As a traditional Chinese therapy,acupuncture offers unique advantages in alleviating breast cancer-related symptoms;however,its direct anti-tumor effects and underlying mechanisms require further clarification.Organizing and comparing ideal and stable animal models are crucial for in-depth research on breast cancer development and progression,as well as for exploring the interventional effects of acupuncture.This article systematically reviews the establishment method,characteristics,and applications of five types of animal models for breast cancer:spontaneous,induced,transplanted,transgenic,and syndrome combination.Types of acupuncture interventions used in animal models,acupuncture parameters,acupoint selection patterns,and evaluation indicators of effects are also summarized.The findings provide a reference for investigating the anti-breast cancer effects and mechanisms of acupuncture,laying an experimental foundation for subsequent research and clinical translation.关键词
乳腺癌/动物模型/针刺干预/病证结合Key words
breast cancer/animal models/acupuncture intervention/disease-syndrome combination分类
生物科学引用本文复制引用
冯光景,夏绮联,王柯莹,吴林纳,李文雅,余雨彤,陈袁幸,徐月川,赵荣..乳腺癌动物模型的构建方法及针刺干预效应研究现状[J].中国实验动物学报,2026,34(7):1036-1048,13.基金项目
国家自然科学基金项目(81760896),云南省教育厅科学研究基金项目(2025Y0609),云南省傣医药与彝医药重点实验室开放课题(2024SS24005). Funded by National Natural Science Foundation of China(81760896),Scientific Research Fund Project of Yunnan Provincial Department of Education(2025Y0609),Open Project of Yunnan Provincial Key Laboratory of Dai and Yi Medicines(2024SS24005). （81760896）
