中国实验动物学报2026，Vol.34Issue(7)：1049-1060,12.DOI:10.3969/j.issn.1005-4847.2026.07.010
毒品记忆和神经突触可塑性在毒品成瘾中的研究进展
Drug memory and synaptic plasticity in drug addiction
摘要
Abstract
Drug addiction is a complex neuro-psychiatric disorder involving long-term adaptive brain changes in reward and memory that lead to drug abuse.The interaction between pathological drug memory and neural synaptic plasticity has become the core focus of addiction mechanism research.Pathological drug memory is a highly consolidated and difficult-to-erase conditional memory formed in response to drug-related cues,its abnormal firmness and inability to be forgotten are the key driving factors for relapse behavior.Neural synaptic plasticity mediates long-term neural circuitry modification by drugs through the dynamic synaptic structure and function adjustment.This article reviews the association between pathological drug memory and neural synaptic plasticity and explains the specific molecular and cellular mechanisms of drug memory encoding,consolidation,and retrieval for different types of drugs(including methamphetamine,cocaine,cannabis,heroin,and new psychoactive substances).By examining the specific pathways and targets that regulate different synaptic plasticities,this article aims to provide a theoretical basis and research directions for addiction treatment strategies targeting memory intervention and synaptic plasticity regulation.关键词
毒品成瘾/毒品记忆/突触可塑性/记忆印迹Key words
drug addiction/drug memory/synaptic plasticity/memory imprint分类
生物科学引用本文复制引用
王敏,许睿珂,李利华,洪仕君,刘超,杨根梦..毒品记忆和神经突触可塑性在毒品成瘾中的研究进展[J].中国实验动物学报,2026,34(7):1049-1060,12.基金项目
国家自然科学基金(82202081,82560336),云南省科技厅基础研究项目(202301AT070269,202301AU070216),云南省科技厅-昆医联合专项(202301AY070001-234,202501AY 070001-002),昆明医科大学高层次人才科研配套费(K132310593). Funded by National Natural Science Foundation of China(82202081,82560336),Basic Research Project of Yunnan Provincial Science and Technology Department(202301AT070269,202301AU070216),Joint Special Project of Yunnan Provincial Science and Technology Department and Kunming Medical University(202301AY070001-234,202501AY070001-002),Start-up Research Fund for High-Level Talents of Kunming Medical University(K132310593). （82202081,82560336）
