中国畜牧杂志2026，Vol.62Issue(8)：69-76,8.DOI:10.19556/j.0258-7033.20260615-14
基因组结构变异在地方猪资源保护与分子育种中的应用
Application of Genomic Structural Variants in Local Pig Germplasm Conservation and Molecular Breeding
摘要
Abstract
Genomic structural variation(SV)represents a major category of genetic variation in the pig genome and contributes to breed differentiation,environmental adaptation,and the formation of economically important traits by altering gene copy numbers,disrupting regulatory sequences,and reshaping local genomic architectures.With the rapid development of whole-genome resequencing,long-read third-generation sequencing,and pangenomic technologies,research on SVs in indigenous pig breeds has gradually expanded toward the detection and population-scale analysis of diverse SV types,including deletions,insertions,duplications,inversions,translocations,and mobile element insertions.However,current studies still face several challenges,such as inconsistent classification criteria among SV types,limited comparability of detection results across different platforms,insufficient functional evidence for candidate loci,and weak foundations for breeding applications.This review article summarizes recent advances in the definition and classification of SVs,detection methodologies,distribution characteristics,and their applications in the conservation of indigenous pig genetic resources and molecular breeding.Furthermore,it is proposed that candidate SV loci should undergo reliable genotyping,independent population validation,and functional verification before they can be regarded as robust molecular markers for practical breeding programs.关键词
猪/结构变异/拷贝数变异/种质资源/分子育种Key words
Pig/Structural variation/Copy number variation/Germplasm resources/Molecular breeding分类
农业科技引用本文复制引用
田作坤,李韦,丁月云,殷宗俊..基因组结构变异在地方猪资源保护与分子育种中的应用[J].中国畜牧杂志,2026,62(8):69-76,8.基金项目
国家自然科学基金(32573167) （32573167）
基于基因组信息分析的皖南花猪家系与生物安全防控优化项目(HX20250823) （HX20250823）
