中国医学前沿杂志（电子版）2026，Vol.18Issue(6)：31-37,7.DOI:10.12037/YXQY.2026.06-06
非小细胞肺癌组织中Wilms肿瘤1相关蛋白、含PEST的核蛋白表达与病理特征及预后的关系
The relationship between the expression of Wilms tumor 1-associated protein and PEST-containing nuclear protein in non-small cell lung cancer and pathological features and prognosis
摘要
Abstract
Objective To investigate the expression characteristics of Wilms tumor 1-associated protein(WTAP)and PEST-containing nuclear protein(PCNP)in non-small cell lung cancer(NSCLC)tissues and to analyze their correlations with pathological features and prognosis.Methods From February 2018 to February 2020,189 NSCLC patients admitted to Xuchang Central Hospital were enrolled.Cancer tissues and paired adjacent non-tumor tissues were enrolled.Cancer tissue specimens and paired adjacent non-cancerous tissue specimens were collected.The expression of WTAP and PCNP in tissues was detected by immunohistochemistry.The expression differences of WTAP and PCNP in NSCLC tissues with different pathological characteristics were compared.The patients were followed up for 5 years after the operation.The Kaplan-Meier survival curve was used to compare the differences in overall survival(OS)and progressin free survival(PFS)among patients with different expression levels of WTAP and PCNP,and the multivariate Cox proportional hazards regression model was used to evaluate the risk factors affecting the prognosis of NSCLC patients.Results The positive rates of WTAP and PCNP in NSCLC cancer tissues were higher than those in adjacent tissues(P<0.05),and the expression of WTAP was positively correlated with that of PCNP(rs=0.502,P<0.001).The positive rates of WTAP and PCNP in NSCLC tissues with TNM stageⅢa,poor differentiation,lymph node metastasis and tumor invasion were all higher than those in NSCLC tissues with TNM stage Ⅰ-Ⅱ,moderate to high differentiation,no lymph node metastasis and no tumor invasion(P<0.05).During the follow-up period,3 cases were lost to follow-up,25 cases relapsed,17 cases metastasized,59 cases died,and 127 cases survived.The 5-year PFS rate and 5-year OS rate of NSCLC patients with positive expression of WTAP and PCNP were lower than those of NSCLC patients with negative expression of WTAP and PCNP(WTAP:37.89%vs.53.85%,63.64%vs.79.63%,Log-rank χ2=12.890,4.720,all P<0.05;PCNP:40.68%vs.54.41%,62.71%vs.77.94%,Log-rank χ2=5.122,5.131,all P<0.05).Multivariate Cox regression showed that TNM stageⅢa,positive expression of WTAP,and positive expression of PCNP were risk factors for death in NSCLC patients during the follow-up period(P<0.05).Conclusions The positive expressions of WTAP and PCNP in NSCLC tissues are related to malignant pathological characteristics and poor prognosis.关键词
非小细胞肺癌/病理特征/预后/Wilms肿瘤1相关蛋白/含PEST的核蛋白Key words
Non-small cell lung cancer/Pathological features/Prognosis/Wilms tumor 1-associated protein/PEST-containing nuclear protein引用本文复制引用
王鹏远,孙颖川,刘志,董雪茹,尹钊,王坤龙,介睿峥..非小细胞肺癌组织中Wilms肿瘤1相关蛋白、含PEST的核蛋白表达与病理特征及预后的关系[J].中国医学前沿杂志（电子版）,2026,18(6):31-37,7.基金项目
河南省科技攻关(指导立项)(232102310132,242102310240) Research Project Approval by the Department of Science and Technology of Henan Province(232102310132,242102310240) （指导立项）
