中国医学前沿杂志（电子版）2026，Vol.18Issue(6)：63-69,7.DOI:10.12037/YXQY.2026.06-10
嘌呤能系统在癫痫机制中的作用及诊疗研究进展
Advances in the role of the purinergic system in epileptic mechanisms and its diagnosis and treatment
摘要
Abstract
Epilepsy is a common chronic neurological disease.Current clinical diagnosis mainly relies on medical history and electroencephalography,which has certain limitations.Existing treatments mainly focus on seizure control but are unable to halt disease progression,and approximately 30%of patients have drug-resistant epilepsy with poor prognosis.In recent years,studies have found that the purinergic system plays an important role in regulating neuronal excitability and neuroinflammation,and the imbalance between the ATP-P2X7R signaling pathway and the adenosine-A1R signaling pathway is involved in the occurrence and development of epilepsy.Molecules related to this system have shown application value in the multi-dimensional diagnosis of epilepsy,and targeted intervention strategies for this system also have broad prospects,but clinical translation still faces challenges.This article systematically reviews the role of the purinergic system in epilepsy,focuses on evaluating its application value in clinical diagnosis and treatment,and provides a theoretical basis and strategies for achieving precision diagnosis and treatment of epilepsy.关键词
癫痫/嘌呤能系统/腺苷/P2X7受体/诊断/抗癫痫治疗Key words
Epilepsy/Purinergic system/Adenosine/P2X7 receptor/Diagnosis/Antiepileptic therapy引用本文复制引用
彭雪影,姬辛娜,陈倩..嘌呤能系统在癫痫机制中的作用及诊疗研究进展[J].中国医学前沿杂志（电子版）,2026,18(6):63-69,7.基金项目
Capital's Funds for Health Improvement and Research(2022-2Z-2104) （2022-2Z-2104）
Beijing Municipal Science&Technology Plan Program(Z251100004625063) 首都卫生发展科研专项项目(首发2022-2Z-2104) （Z251100004625063）
北京市科技计划项目(Z251100004625063) （Z251100004625063）
