中国中西医结合外科杂志2026，Vol.32Issue(4)：497-501,5.DOI:10.3969/j.issn.1007-6948.2026.04.007
祛瘀生肌散联合裸花紫珠胶囊对肛瘘患者术后创面愈合、疼痛及血清前列腺素E2、趋化因子受体4及血管内皮细胞生长因子的影响
Effects of Quyu Shengji powder combined with Luohua Zizhu capsules on postoperative wound healing,pain,and serum PGE-2,CXCR4,VEGF levels in patients with anal fistula
摘要
Abstract
Objective To study the effects of Quyu Shengji powder combined with Luohua Zizhu capsules on wound healing,pain,and serum prostaglandin E2(PGE-2),C-X-C chemokine receptor 4(CXCR4),and vascular endothelial growth factor(VEGF)levels in patients with anal fistula after surgery.Methods From March 2022 to March 2025,90 patients with complex anal fistula who received surgical therapy at our hospital were selected.Patients were randomly separated into the reference group(Luohua Zizhu capsules)and the therapy group(Quyu Shengji powder+Luohua Zizhu capsules),with 45 cases per group.The efficacy,wound healing indicators,wound symptom scores,serum PGE-2,CXCR4,VEGF levels,anal function[anal longest contraction time(ALCT),anal resting pressure(ARP),and severity of fecal incontinence(Wexner)scale]were compared.Results The therapy group had a greater overall effective rate(91.11％)than the reference group(75.56％),and the therapy group had prominently shorter wound healing time than the reference group(P＜0.05).After therapy,the therapy group had smaller wound exudate volume,wound symptom score,VAS score,PGE-2,CXCR4,and Wexner,and larger VEGF,ARP,and ALCT than the reference group(P＜0.05).Conclusion The application of Quyu Shengji powder combined with Luohua Zizhu capsules in postoperative therapy of anal fistula patients can prominently ameliorate clinical efficacy,effectively promote wound healing,shorten healing time,reduce wound exudation and symptom manifestations,relieve patient pain,regulate serum PGE-2,CXCR4,VEGF levels,and improve anal function.关键词
祛瘀生肌散/裸花紫珠/肛瘘/创面愈合/趋化因子受体4Key words
Quyu Shengji powder/Luohua Zizhu capsules/anal fistula/wound healing/C-X-C chemokine receptor 4分类
医药卫生引用本文复制引用
刘晓明,彭彪,高晓楠..祛瘀生肌散联合裸花紫珠胶囊对肛瘘患者术后创面愈合、疼痛及血清前列腺素E2、趋化因子受体4及血管内皮细胞生长因子的影响[J].中国中西医结合外科杂志,2026,32(4):497-501,5.基金项目
河北省中医药管理局科研项目(2023375) （2023375）
