中国中医骨伤科杂志2026，Vol.34Issue(8)：6-13,8.DOI:10.20085/j.cnki.issn1005-0205.260802
补肾除湿方联合关节镜下自体骨软骨移植术治疗膝骨关节炎
Bushen Chushi Formula Combined with Arthroscopic Autologous Osteochondral Transplantation for the Treatment of Knee Osteoarthritis
摘要
Abstract
Objective:To explore the efficacy and safety of the Bushen Chushi formula combined with arthroscopic autolo-gous osteochondral transplantation(AOT)in the treatment of early-to middle-stage knee osteoarthritis(KOA).Meth-ods:The clinical data of 45 patients with knee osteoarthritis,collected from November 2023 to December 2024,were ana-lyzed.Patients were divided into an observation group(n=25)and a control group(n=20)using a random number ta-ble.The WOMAC osteoarthritis pain index scores,Lequesne index scores,knee joint range of motion,and levels of inflam-matory factors were analyzed before surgery,2 weeks after surgery,and 4 weeks after surgery.Results:There was no sta-tistically significant difference in the WOMAC and Lequesne index scores between the two groups before surgery(P>0.05).The WOMAC osteoarthritis pain index scores,Lequesne index scores,and knee joint range of motion of both groups were better than those before surgery 2 weeks and 4 weeks after surgery(P<0.05).There was no statistically significant difference in the serum indicators of interleukin 6(IL-6),matrix metalloproteinase 13(MMP-13),and matrix metalloproteinase 3(MMP-3)between the two groups before surgery(P>0.05).The serum indicators of IL-6,MMP-13,and MMP-3 measured 2 weeks and 4 weeks after surgery were better than those before surgery(P<0.05).Conclusion:The combination of the Bushen Chushi formula and the arthroscopic autologous bone and cartilage transplan-tation surgery can significantly alleviate the pain symptoms of patients with early-to mid-stage knee osteoarthritis and improve the joint function of the affected limb.关键词
膝骨关节炎/自体骨软骨移植/关节镜/补肾除湿方Key words
knee osteoarthritis/autologous osteochondral transplantation/arthroscopy/Bushen Chushi formula分类
医药卫生引用本文复制引用
王晓庆,闫奇,葛琪瑞,荆琳,陈博弈,黄立远,麻启明,徐可..补肾除湿方联合关节镜下自体骨软骨移植术治疗膝骨关节炎[J].中国中医骨伤科杂志,2026,34(8):6-13,8.基金项目
中国中医科学院望京医院高水平中医医院建设项目中医药临床循证研究专项(WJYY-XZKT-2023-31)北京市科技委员会基金项目(Z201100005520058) （WJYY-XZKT-2023-31）
