中国中医骨伤科杂志2026，Vol.34Issue(8)：72-78,7.DOI:10.20085/j.cnki.issn1005-0205.260810
基于《金匮要略》血痹理论探讨线粒体自噬与氧化应激调节在膝骨关节炎治疗中的作用
Exploring the Role and Mechanism of Mitophagy and Oxidative Stress Regulation in the Treatment of Knee Osteoarthritis Based on the Blood Impediment Theory in Synopsis of the Golden Chamber
摘要
Abstract
Knee osteoarthritis(KOA)is a globally prevalent chronic degenerative joint disease,whose clinical pathogenesis has not been fully elucidated.Recent studies have shown that the vicious cycle formed by the dysregulation of chondrocyte mitophagy and the imbalance of oxidative stress constitutes the core pathological link in the progression of KOA.Tradi-tional Chinese medicine(TCM)has unique advantages in the treatment of KOA.The blood stasis theory from Synopsis of the Golden Chamber takes"deficiency at the root and excess in branch"as its core pathological model,wherein"defi-ciency in root"can correspond to the pathological basis of mitochondrial dysfunction and decreased antioxidant capacity,while"excess in branch"reflects the pathological state of mitophagy dysregulation and oxidative stress imbalance.Based on the blood impediment theory and combined with modern medical research findings,this paper—through a literature re-view and theoretical analysis—proposes that TCM may exert therapeutic effects by regulating the balance between mito-phagy and oxidative stress and disrupting their vicious cycle,thereby providing a theoretical foundation for expanding TCM treatment strategies and mechanistic research on KOA.关键词
膝骨关节炎/金匮要略/血痹理论/线粒体自噬/氧化应激/中医药治疗Key words
knee osteoarthritis/Synopsis of the Golden Chamber/blood impediment theory/mitophagy/oxidative stress/traditional Chinese medicine treatment分类
医药卫生引用本文复制引用
赵千乐,袁普卫,刘德玉,康武林,杨波,董佩,赵泽龙,李学同,尚辉..基于《金匮要略》血痹理论探讨线粒体自噬与氧化应激调节在膝骨关节炎治疗中的作用[J].中国中医骨伤科杂志,2026,34(8):72-78,7.基金项目
国家中医药管理局2018年全国名老中医药专家传承工作室建设项目(国中医药人教函[2018]134号)长安医学关中李氏骨伤学术流派传承工作室建设项目(陕中医药发[2018]40号)陕西省教育厅科研项目(陕教函[2025]96号) （国中医药人教函[2018]134号）
