中国中医基础医学杂志2026，Vol.32Issue(8)：1668-1672,5.
基于"卫气内伐"理论探讨免疫检查点抑制剂相关消化系统毒性的诊治
Exploring the Diagnosis and Treatment of Digestive System Toxicity Related to Immune Checkpoint Inhibitors Based on the Theory of"Defensive Qi Internal Logging"
摘要
Abstract
Immune checkpoint inhibitors(ICIs)are one of the breakthrough achievements in the field of tumor immunotherapy,but they also bring a series of immune related adverse reactions.Among them,digestive system toxicity accounts for a considerable proportion.ICIs related gastrointestinal toxicity shares high similarities with autoimmune hepatitis,inflammatory bowel disease,and other rheumatic and autoimmune diseases in terms of pathogenesis,clinical manifestations,and treatment.The theory of"defensive Qi internal logging"originated from the Inner Canon of Huangdi and later became one of the important academic ideas for rheumatic and immune diseases.Drawing on the theory of"defensive Qi internal logging"to analyze the digestive system toxicity of ICIs,it was found that they are related to abnormal ascending and descending,exiting and entering of defensive Qi or insufficient energy of the nutrient Qi.Therefore,diffusing the lung and clearing the intestine to restore the ascending and descending of the defensive Qi,eliminating blood stasis and removing dampness to dredge the channel of defensive Qi movement,soothing liver and regulating Qi to restore the exiting and entering of defensive Qi,replenishing Qi and nourishing blood to nourish the nutrient Qi can restore the normal physiological function of the defensive Qi and achieve the goal of treating ICIs related digestive system toxicity.关键词
卫气内伐/免疫检查点抑制剂/消化系统毒性Key words
Defensive Qi internal logging/Immune checkpoint inhibitors/Digestive system toxicity分类
医药卫生引用本文复制引用
高盈恺,王海隆,沈洋..基于"卫气内伐"理论探讨免疫检查点抑制剂相关消化系统毒性的诊治[J].中国中医基础医学杂志,2026,32(8):1668-1672,5.基金项目
第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号) （国中医药人教函[2022]1号）
2023年度东城区优秀人才培养项目(2023-dchrcpyyz-3) （2023-dchrcpyyz-3）
中国中医科学院西苑医院提升中医药临床循证证据级别研究专项面上项目(XYZX0201-19) （XYZX0201-19）
