中国合理用药探索2026，Vol.23Issue(7)：8-13,6.DOI:10.3969/j.issn.2096-3327.2026.07.002
依那普利联合非洛地平对原发性高血压合并冠心病患者血压变异性及晚期氧化蛋白产物的影响
Effects of Enalapril Combined with Felodipine on Blood Pressure Variability and Advanced Oxidation Protein Products in Patients with Essential Hypertension and Coronary Heart Disease
摘要
Abstract
Objective:To investigate the effects of enalapril combined with felodipine on blood pressure variability(BPV)and advanced oxidation protein products(AOPP)levels in patients with essential hypertension and coronary heart disease(CHD).Methods:A total of 110 patients with essential hypertension and CHD who were treated at our hospital between July 2021 and December 2023 were enrolled.Using a random-number table method,patients were assigned to a control group(felodipine)or an observation group(enalapril plus felodipine),with 55 patients in each group.The following outcomes were compared between the two groups:BPV parameters,including mean daytime(d),nighttime(n),and 24-hour systolic blood pressure(SBP),diastolic blood pressure(DBP),systolic blood pressure coefficient of variation(SCV),and diastolic blood pressure coefficient of variation(DCV);AOPP levels;clinical efficacy;and adverse reactions.Results:After treatment,dSBP,nSBP,24 h SBP,dDBP,nDBP,24 h DBP,dSCV,nSCV,24 h SCV,dDCV,nDCV,24 h DCV,and AOPP levels decreased in both groups and were significantly lower in the observation group than in the control group(P<0.05).The overall response rate was significantly higher in the observation group than in the control group(94.55%vs.81.82%,P<0.05).The total incidence of adverse reactions did not differ significantly between the two groups(P>0.05).Conclusion:Enalapril combined with felodipine was effective in patients with essential hypertension and CHD,can reduce the expression levels of BPV and AOPP,and there was no increase in the risk of adverse reactions.关键词
依那普利/非洛地平/原发性高血压/冠心病/血压变异性/晚期氧化蛋白产物Key words
enalapril/felodipine/essential hypertension/coronary heart disease/blood pressure variability/advanced oxidation protein products分类
医药卫生引用本文复制引用
龙晓飞,宋亚楠,冀建伟,李涵,曹斌..依那普利联合非洛地平对原发性高血压合并冠心病患者血压变异性及晚期氧化蛋白产物的影响[J].中国合理用药探索,2026,23(7):8-13,6.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20190305) （LHGJ20190305）
