中国合理用药探索2026，Vol.23Issue(7)：28-33,6.DOI:10.3969/j.issn.2096-3327.2026.07.005
渐进抗阻训练联合A型肉毒毒素对痉挛型脑瘫患儿下肢肌痉挛及运动能力的影响
Effects of Progressive Resistance Training Combined with Type A Botulinum Toxin on Lower-Limb Muscle Spasticity and Motor Ability in Children with Spasticity Cerebral Palsy
摘要
Abstract
Objective:To investigate the effects of progressive resistance training(PRT)combined with type A botulinum toxin(BTX-A)on lower-limb muscle spasticity and motor ability in children with spasticity cerebral palsy(SCP).Methods:This prospective study included 80 children with SCP treated at our hospital from January 2021 to December 2023.They were randomly divided into a control group(BTX-A)and an observation group(PRT combined with BTX-A)using a random number table method,with 40 cases in each group.Lower-limb muscle spasticity[Modified Ashworth Scale(MAS)score],gait parameters(step width,step length and walking speed),motor ability[Gross Motor Function Measure-88(GMFM-88)scores],and adverse reactions were observed before and after treatment in both groups.Results:After treatment,MAS scores decreased in both groups and were lower in the observation group than in the control group(P<0.05).Step width decreased and was shorter in the observation group than in the control group(P<0.05);step length increased and was longer in the observation group than in the control group(P<0.05);walking speed increased and was faster in the observation group than in the control group(P<0.05).GMFM-88 dimension D and E scores and their combined total score increased and were higher in the observation group than in the control group(P<0.05).There was no statistically significant difference in the incidence of injection-site pain between the two groups(P>0.05).The incidence of transient muscle weakness was lower in the observation group(42.50%)than in the control group(65.00%,P<0.05).Conclusion:PRT combined with BTX-A can alleviate lower-limb muscle spasticity,correct abnormal gait,improve motor ability,and reduce the incidence of transient muscle weakness in children with SCP.关键词
渐进抗阻训练/A型肉毒毒素/痉挛型脑瘫/下肢肌痉挛/运动能力Key words
progressive resistance training/type A botulinum toxin/spasticity cerebral palsy/lower-limb muscle spasticity/motor ability分类
医药卫生引用本文复制引用
牛冬林,马丹丹,罗丽,程明高,刘锋伟..渐进抗阻训练联合A型肉毒毒素对痉挛型脑瘫患儿下肢肌痉挛及运动能力的影响[J].中国合理用药探索,2026,23(7):28-33,6.基金项目
河南省医学科技攻关计划项目(LHGJ20200426) （LHGJ20200426）
