中国合理用药探索2026，Vol.23Issue(7)：40-46,7.DOI:10.3969/j.issn.2096-3327.2026.07.007
甲钴胺联合神经肌肉电刺激对周围神经损伤性关节疼痛的疗效观察
Efficacy of Mecobalamin Combined with Neuromuscular Electrical Stimulation for Joint Pain Associated with Peripheral Nerve Injury
摘要
Abstract
Objective:To preliminarily evaluate the effects of mecobalamin combined with neuromuscular electrical stimulation(NMES)on pain intensity,nerve conduction,and joint mobility in patients with joint pain associated with peripheral nerve injury.Methods:A single-center,randomized,open-label,outcome assessor-blinded,controlled clinical study was conducted.A total of 86 patients with joint pain associated with peripheral nerve injury who presented to our hospital between January 2023 and January 2025 were assigned in a 1∶1 ratio to a control group or an observation group using a random number table method,with 43 patients in each group.Both groups received basic rehabilitation therapy.The control group additionally received NMES,while the observation group received mecobalamin in addition to the control-group regimen.Both groups were treated for 4 weeks.Pain intensity[assessed using the Visual Analogue Scale(VAS)],nerve conduction[motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)],joint mobility[range of motion(ROM)],clinical efficacy,and the incidence of adverse events were compared between the groups.Results:After 4 weeks of treatment,VAS scores decreased from baseline in both groups,with a greater reduction in the observation group than in the control group(P<0.05).MNCV,SNCV,and ROM increased from baseline in both groups,with greater increases in the observation group than in the control group(P<0.05).The overall clinical response rate was higher in the observation group than in the control group(93.02%vs 74.42%,P<0.05).No serious adverse events occurred in either group during treatment.Adverse events,including local skin erythema,dizziness,and nausea,were mild,and the overall incidence of adverse events did not differ significantly between the groups(P>0.05).Conclusion:Mecobalamin combined with NMES alleviated joint pain associated with peripheral nerve injury and improved nerve conduction and joint mobility,with acceptable short-term safety.关键词
甲钴胺/神经肌肉电刺激/周围神经损伤/关节疼痛/视觉模拟评分法Key words
mecobalamin/neuromuscular electrical stimulation/peripheral nerve injury/joint pain/Visual Analogue Scale分类
医药卫生引用本文复制引用
宋书亚,李和平,陈希荣,刘鹏..甲钴胺联合神经肌肉电刺激对周围神经损伤性关节疼痛的疗效观察[J].中国合理用药探索,2026,23(7):40-46,7.基金项目
中国康复医学会项目(KFKT-2023-031) （KFKT-2023-031）
