中国兽药杂志2026，Vol.60Issue(7)：12-19,8.DOI:10.11751/ISSN.1002-1280.2026.7.02
一种测定铁剂中苯酚含量的理化检测方法研究
Research on a Physicochemical Detection Method for Determining Phenol Content in Iron Agents
王光娥 1何克甜 2黄炳辰 3陆泽宁 4韦良云5
作者信息
- 1. 广西南宁市桃源兽药厂,南宁 530104
- 2. 南宁市武鸣区陆斡镇水产畜牧兽医站,南宁 530111
- 3. 南宁市武鸣区罗波镇水产畜牧兽医站,南宁 530112
- 4. 南宁市武鸣区双桥镇水产畜牧兽医站,南宁 530104
- 5. 广西壮族自治区兽药监察所,南宁 530001
- 折叠
摘要
Abstract
Phenol serves as a bacteriostatic agent in iron dextran injection,but its toxicity necessitates strict control at the minimum effective concentration.Currently,methods for determining phenol content in iron dextran are limited and involve high detection costs.A combined back-titration method for impurity removal by iron-sodium dihydrogen phosphate precipitation was established for the physicochemical detection of phenol content in iron dextran injection/solution.The results showed that the phenol concentration had a good linear relationship within the range of 1.25～16.95 mg/mL.Taking the amount of phenol added(mg)as the abscissa and V0-V(mL)as the ordinate,the regression equation was y=0.1565x-0.0158,r=0.9995.The recovery rate was 95.7%～104.0%.The precision relative stanfard deviation(RSD)is 0.8%.This method does not require precision instruments,is easy to operate,and has a low cost.It can meet the quality requirements of foreign customers and provide domestic iron veterinary drug manufacturers with an economical and efficient quality control means,and also offers a reference for the revision of national standards and quality and safety control of iron dextran injection/solution.关键词
沉淀除杂/反滴定/右旋糖酐铁注射液/溶液/苯酚含量检测Key words
sedimentation and impurity removal/reverse titration/iron dextran injection/solution/detection of phenol content分类
农业科技引用本文复制引用
王光娥,何克甜,黄炳辰,陆泽宁,韦良云..一种测定铁剂中苯酚含量的理化检测方法研究[J].中国兽药杂志,2026,60(7):12-19,8.
