转化医学杂志2026，Vol.15Issue(8)：1261-1265,5.DOI:10.3639/j.issn.2095-3097.2026.08.001
D-二聚体/纤维蛋白原比值对老年血管外科危重症患者院内死亡的预测价值
Predictive Value of D-dimer/Fibrinogen Ratio for In-Hospital Mortality in Elderly Critically Ill Patients Undergoing Vascular Surgery
摘要
Abstract
Objective To explore the predictive value of the D-dimer to fibrinogen ratio(DFR)at admission for in-hospital mortality among elderly critically ill patients in vascular surgery.Methods A total of 132 elderly patients with vascular diseases admitted to the Intensive Care Unit(ICU)of Beijing Friendship Hospital,Capital Medical University from January 2021 to June 2025 were retrospectively enrolled and categorized into survival group(n=114)and non-survival group(n=18)according to in-hospital outcomes.Multivariate logistic regression was used to analyze the risk factors for mortality in elderly critically ill patients in vascular surgery and their association with organ function.ROC curves were utilized to evaluate the predictive value of DFR for mortality in these patients.Results The age,heart rate,lactate levels,white blood cell count,urea,D-dimer,DFR,creatinine,and N-terminal pro-B-type natriuretic peptide in the non-survival group were significantly higher than those in the survival group.Conversely,the surgical treatment total length of hospital stay,non-ICU stay,non-mechanical ventilation days,and oxygenation index were lower in the non-survival group than in the survival group(P<0.05).Multivariate logistic regression analysis indicated that an elevated DFR is an independent risk factor for mortality in elderly patients with vascular diseases(OR=1.768,95％CI:1.013-3.097,P=0.047).ROC curve analysis demonstrated that the AUC for DFR in predicting mortality among elderly patients with vascular diseases was 0.952.Furthermore,an elevated DFR was associated with a decreased oxygenation index and thrombocytopenia(P<0.05),and its predictive value was superior in the subgroup of thrombosis-related diseases.Conclusion DFR is an independent risk factor for predicting adverse prognoses in elderly critically ill patients in vascular surgery.This indicator can effectively identify potential abnormalities in the"lung-coagulation axis"and the risk of occult respiratory failure,thereby facilitating early clinical stratification and intervention.关键词
D-二聚体/纤维蛋白原比值/老年/血管外科危重症/病死率/免疫血栓Key words
D-dimer/fibrinogen ratio/elderly/critically ill vascular surgery patients/in-hospital mortality/immunothrombosis引用本文复制引用
刘钊,额尔敦必力格,刘彬,张立伟,冯海..D-二聚体/纤维蛋白原比值对老年血管外科危重症患者院内死亡的预测价值[J].转化医学杂志,2026,15(8):1261-1265,5.基金项目
首都卫生发展科研专项项目(2020-2-1102) （2020-2-1102）
