转化医学杂志2026，Vol.15Issue(8)：1279-1284,6.DOI:10.3639/j.issn.2095-3097.2026.08.004
MPP进展为塑型性支气管炎患儿临床特征及血清PCT、D-D、NLR对进展的预测价值
Clinical Characteristics of Pediatric Patients with Mycoplasma Pneumoniae Pneumonia Progressing to Plastic Bronchitis and Predictive Value of Serum PCT,D-D and NLR for Disease Progression
摘要
Abstract
Objective To analyze the clinical characteristics of children with Mycoplasma pneumoniae pneumonia(MPP)progressing to plastic bronchitis(PB)and the predictive value of serum procalcitonin(PCT),D-dimer(D-D)and neutrophil-to-lymphocyte ratio(NLR)for the progression risk.Methods One hundred and six children with MPP progressing to PB admitted to Shanxi Children's Hospital from April 2024 to October 2025 were retrospectively enrolled as the study group(n=106),and 106 children with MPP without progression during the same period were selected at a 1:1 ratio as the control group(n=106).Clinical data and laboratory indicators within 24 hours after admission,including white blood cell count,erythrocyte sedimentation rate,platelet count,C-reactive protein,lactate dehydrogenase,PCT,D-D and NLR,were compared between the two groups.The correlation between serum PCT,D-D and NLR levels and progression to PB in children with MPP was analyzed.Multivariate conditional Logistic regression analysis and receiver operating characteristic(ROC)curve analysis were performed to assess the predictive value of related indicators for progression to PB in children with MPP.Results The length of hospital stay and duration of fever in the study group were significantly longer than those in the control group(P<0.05),and the proportion of children with pleural effusion was significantly higher in the study group than in the control group(P<0.05).The levels of erythrocyte sedimentation rate,C-reactive protein,lactate dehydrogenase,PCT,D-D and NLR in the study group were significantly higher than those in the control group(P<0.05).Multivariate conditional Logistic regression analysis showed that pleural effusion and elevated serum levels of PCT,D-D and NLR were independent risk factors for progression to PB in children with MPP(all P<0.05).ROC curves revealed that the area under the curve(AUC)of serum PCT,D-D and NLR in predicting progression to PB in children with MPP was 0.830,0.862 and 0.779,respectively,and the AUC of the combined diagnosis of the three indicators was 0.894,indicating that each single indicator and the combined diagnosis had favorable predictive value.Conclusion Pleural effusion and serum levels of PCT,D-D and NLR are significantly correlated with progression to PB in children with MPP,and the above serum indicators have high predictive value for the disease progression of MPP.关键词
肺炎支原体肺炎/塑型性支气管炎/降钙素原/D-二聚体/中性粒细胞/淋巴细胞比值Key words
mycoplasma pneumoniae pneumonia/plastic bronchitis/procalcitonin/D-dimer/neutrophil-to-lymphocyte ratio引用本文复制引用
陈慧婧,王芳,张润平,高吊清,李晓霞,聂晶,王荣华..MPP进展为塑型性支气管炎患儿临床特征及血清PCT、D-D、NLR对进展的预测价值[J].转化医学杂志,2026,15(8):1279-1284,6.基金项目
山西省应用基础研究计划项目(201901D111424) （201901D111424）
