转化医学杂志2026，Vol.15Issue(8)：1285-1289,5.DOI:10.3639/j.issn.2095-3097.2026.08.005
miR-26a-5p和miR-708-3p对急性胸痛病因急性心肌梗死的诊断价值
The Diagnostic Value of miR-26a-5p and miR-708-3p for Acute Myocardial Infarction Among Etiologies of Acute Chest Pain
摘要
Abstract
Objective To investigate the clinical value of serum microRNA-26a-5p(miR-26a-5p)and microRNA-708-3p(miR-708-3p)in acute myocardial infarction(AMI)in patients with acute chest pain(ACP).Methods A total of 237 patients who presented to the emergency department of Shijiazhuang People's Hospital with ACP from January 2022 to December 2024 and were diagnosed with AMI,acute pulmonary embolism(APE),or acute aortic dissection(AAD)by relevant examinations were prospectively enrolled as the ACP group.According to etiology,they were divided into AMI patients(n=159)and APE+AAD patients(n=78);according to the HEART score,they were divided into intermediate-to high-risk chest pain patients(n=172)and low-risk chest pain patients(n=65).Meanwhile,172 healthy individuals who underwent physical examination at our hospital during the same period were selected as the control group.Quantitative real-time reverse transcription polymerase chain reaction was used to detect serum levels of miR-26a-5p and miR-708-3p in the control group on the day of physical examination and in the ACP group at 1 h after admission.ROC curve analysis was performed to evaluate the diagnostic value of serum miR-26a-5p and miR-708-3p for AMI among etiologies of ACP.Results Serum levels of miR-26a-5p(0.64 ± 0.20)and miR-708-3p(0.68 ± 0.11)in the ACP group were significantly lower than those in the control group(1.01 ± 0.12 and 1.02 ± 0.08,respectively),with statistically significant differences(P<0.001).Serum levels of miR-26a-5p and miR-708-3p in patients with intermediate-to high-risk chest pain were significantly lower than those in patients with low-risk chest pain(P<0.001).Serum levels of D-dimer,NT-proBNP,miR-26a-5p,and miR-708-3p in AMI patients were significantly lower,while the level of hs-cTnI was significantly higher,than those in patients with APE+AAD(all P<0.001).The AUC of serum miR-26a-5p and miR-708-3p for the diagnosis of AMI as the etiology of ACP were 0.824 and 0.837,respectively.The combined AUC of the two miRNAs was 0.903,and their combined prediction was superior to individual prediction(P<0.05).Conclusion Serum miR-26a-5p and miR-708-3p were significantly decreased in patients with ACP,and the combination of the two had a high diagnostic value for AMI in the etiology of ACP.关键词
微小RNA-26a-5p/微小RNA-708-3p/急性胸痛/急性心肌梗死/急性肺栓塞Key words
microRNA-26a-5p/microRNA-708-3p/acute chest pain/acute myocardial infarction/acute pulmonary embolism引用本文复制引用
宋博超,朱磊,熊敏,王昊,刘星,穆东,陈浩,李世超..miR-26a-5p和miR-708-3p对急性胸痛病因急性心肌梗死的诊断价值[J].转化医学杂志,2026,15(8):1285-1289,5.基金项目
2025年度河北省医学科学研究课题计划项目(20251419) （20251419）
石家庄市科学技术研究与发展计划项目(211460383) （211460383）
