浙江大学学报（农业与生命科学版）2026，Vol.52Issue(4)：548-561,14.DOI:10.3785/j.issn.1008-9209.2026.04.171
再生胰岛衍生蛋白3γ在肠道炎症及肠外疾病中的调控机制与转化潜力
Regenerating islet-derived protein 3-gamma in intestinal inflammation and extraintestinal diseases:regulatory mechanisms and translational potential
摘要
Abstract
Regenerating islet-derived protein 3-gamma(Reg3g),a member of the C-type lectin family,is predomi-nantly expressed in intestinal epithelial cells.Its expression is tightly regulated by multiple factors,including the intestinal microbiota,cytokines,and inflammatory signals.As a key innate immune effector,Reg3g not only exerts direct antibacterial effects by specifically recognizing and binding to peptidoglycan of Gram-positive bacteria but also plays critical roles in maintaining intestinal microbiota homeostasis,enhancing intestinal barrier function,and modulating immune-inflammatory responses.Recent studies have shown that Reg3g also influences the progression of metabolic diseases,liver diseases,and cancers through the gut-organ axis.This article systematically reviews the molecular characteristics and regulatory mechanisms of Reg3g expression,with a focus on its pivotal functions in intestinal inflammation.It further discusses its involvement in extraintestinal diseases and the potential for therapeutic translation,aiming to provide a reference for Reg3g-related basic research and clinical application.关键词
再生胰岛衍生蛋白3γ/炎症性肠病/肠道屏障/肠道菌群/肠-器官轴Key words
regenerating islet-derived protein 3-gamma/inflammatory bowel disease(IBD)/intestinal barrier/intestinal microbiota/gut-organ axis分类
农业科技引用本文复制引用
乔茜,童亦晨,杜华华..再生胰岛衍生蛋白3γ在肠道炎症及肠外疾病中的调控机制与转化潜力[J].浙江大学学报（农业与生命科学版）,2026,52(4):548-561,14.基金项目
国家重点研发计划项目(2023YFD1301104) （2023YFD1301104）
国家自然科学基金项目(32472918). （32472918）
