浙江大学学报（农业与生命科学版）2026，Vol.52Issue(4)：562-571,10.DOI:10.3785/j.issn.1008-9209.2025.12.151
D型氨基酸的营养生理功能研究进展
Research progress on nutritional and physiological functions of D-amino acids
摘要
Abstract
Amino acids are chiral molecules that exist as L-and D-enantiomers.Diets for poultry and livestock are predominantly composed of L-amino acids;however,intestinal microbiota exhibit amino acid racemase activity,which catalyzes the racemization of certain L-amino acids into their respective D-counterparts.Although D-amino acids are not incorporated into host proteins,they serve as neurotransmitters or neuromodulators,participating in the regulation of immune function,inflammatory responses,and microbial homeostasis in animals.This review systematically summarizes the sources,biosynthetic pathways,metabolism,and tissue distribution of D-amino acids,with emphasis on their roles in modulating gut microbiota and immune function,as well as their implications in diseases.Furthermore,we preliminarily discuss the potential mechanisms by which D-amino acid oxidase and the N-methyl-D-aspartate receptor mediate the antibacterial,immunoregulatory,and disease-modulating effects of D-amino acids,aiming to provide a theoretical reference for the rational application of D-amino acids in poultry and livestock production to regulate growth performance and intestinal health.关键词
D型氨基酸/D型氨基酸氧化酶/N-甲基-D-天冬氨酸受体Key words
D-amino acids/D-amino acid oxidase/N-methyl-D-aspartate receptor分类
农业科技引用本文复制引用
甘欣雨,朱云龙,束汶骏,束刚..D型氨基酸的营养生理功能研究进展[J].浙江大学学报（农业与生命科学版）,2026,52(4):562-571,10.基金项目
国家重点研发计划项目(2022YFD1300401). （2022YFD1300401）
