浙江大学学报（农业与生命科学版）2026，Vol.52Issue(4)：585-597,13.DOI:10.3785/j.issn.1008-9209.2025.12.041
吲哚-3-丙酸通过C/EBP同源蛋白基因介导的凋亡通路缓解猪δ冠状病毒感染诱导的肠上皮损伤
Indole-3-propionic acid alleviates porcine deltacoronavirus-induced intestinal epithelial injury via C/EBP homologous protein gene-mediated apoptotic pathway
摘要
Abstract
Porcine deltacoronavirus(PDCoV)infection can cause severe enteritis in piglets,leading to high mortality rates.This study systematically screened indole metabolites with the potential to alleviate PDCoV-associated endoplasmic reticulum stress(ERS)and conducted an investigation into their mechanisms of action.The results showed that PDCoV infection could induce ERS and apoptosis in intestinal epithelial cells.Among various indole compounds,indole-3-propionic acid(IPA)demonstrated a significant inhibitory effect on ERS and concurrently reduced the level of apoptosis.Further validation in porcine small intestinal organoids and mouse infection models confirmed that IPA could specifically inhibit ERS and its mediated apoptosis in duodenal epithelial cells.In conclusion,this study demonstrates that IPA can alleviate PDCoV-induced intestinal epithelial damage by modulating the ERS pathway,providing a new theoretical foundation and empirical support for developing microbiota metabolite-based nutritional intervention strategies against enteric coronaviruses.关键词
猪δ冠状病毒/吲哚-3-丙酸/内质网应激/细胞凋亡Key words
porcine deltacoronavirus/indole-3-propionic acid/endoplasmic reticulum stress/apoptosis分类
农业科技引用本文复制引用
华陈钢,屈阳,朱书,冀伟..吲哚-3-丙酸通过C/EBP同源蛋白基因介导的凋亡通路缓解猪δ冠状病毒感染诱导的肠上皮损伤[J].浙江大学学报（农业与生命科学版）,2026,52(4):585-597,13.基金项目
江苏省农业科技自主创新资金项目[CX(24)1010]. （24）
