浙江大学学报（农业与生命科学版）2026，Vol.52Issue(4)：598-605,8.DOI:10.3785/j.issn.1008-9209.2026.03.071
钙蛋白酶3介导的核内蛋白水解途径研究进展
Research progress on calpain 3-mediated intranuclear proteolytic pathways
摘要
Abstract
Calpain 3(CAPN3)is the sole member of the calpain family that possesses a nuclear localization signal.Although it was initially identified in skeletal muscle and was long regarded as tissue specific,recent studies have demonstrated that CAPN3 is widely expressed across multiple tissues,including the liver,and plays important roles in regulating substrate activity,stability,and subcellular localization.The confirmation of its nuclear presence has heightened interest in CAPN3-mediated intranuclear proteolytic pathways.This review summarizes recent advancements in CAPN3-mediated intranuclear proteolytic pathways,with a particular focus on the nucleolar digestive-organ expansion factor(DEF)-CAPN3 pathway,which is essential for maintaining nucleolar protein homeostasis,and the newly identified CAPN3-polycomb repressive complex 1(PRC1)pathway,which connects proteolysis with epigenetic regulation.Finally,potential avenues for future research are discussed.关键词
钙蛋白酶3/多梳抑制复合物1/消化器官延伸因子/核内蛋白水解途径Key words
calpain 3(CAPN3)/polycomb repressive complex 1(PRC1)/digestive-organ expansion factor(DEF)/intranuclear proteolytic pathway分类
生物科学引用本文复制引用
曾妮,施回..钙蛋白酶3介导的核内蛋白水解途径研究进展[J].浙江大学学报（农业与生命科学版）,2026,52(4):598-605,8.基金项目
国家重点研发计划项目(2023YFA1800602) （2023YFA1800602）
国家自然科学基金项目(32570983). （32570983）
