浙江大学学报（医学版）2026，Vol.55Issue(5)：383-390,8.DOI:10.3724/zdxbyxb-2025-0549
血管内皮生长因子C参与脑膜淋巴管介导β淀粉样蛋白清除的研究进展
Research progress on vascular endothelial growth factor C in meningeal lymphatic vessel-mediated clearance of amyloid β-protein
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by the abnormal deposition of amyloid β-protein(Aβ)as a core pathological feature.Meningeal lymphatic vessels are crucial for Aβ clearance,and their dysfunction accelerates AD progression.Vascular endothelial growth factor C(VEGF-C),through activation of vascular endothelial growth factor receptor 3 and downstream pathways,synergistically promotes lymphangiogenesis,enhances lymphatic permeability,and regulates lymphatic fluid flow,thereby improving Aβ clearance efficiency.Genetic factors and aging-related declines in VEGF-C further impair meningeal lymphatic function,creating a vicious cycle.This review summarizes the mechanisms by which VEGF-C regulates the structure and function of meningeal lymphatic to promote Aβ clearance,synthesizes the evidence that genetic factors and aging contribute to meningeal lymphatic dysfunction through their effects on VEGF-C,and discusses the prospects of individualized intervention strategies for Alzheimer's disease based on VEGF-C-mediated modulation of meningeal lymphatics,aiming to provide insights for AD prevention and treatment.关键词
阿尔茨海默病/血管内皮生长因子/脑膜淋巴管/β淀粉样蛋白/综述Key words
Alzheimer's disease/Vascular endothelial growth factor/Meningeal lymphatic vessel/Amyloid β-protein/Review分类
医药卫生引用本文复制引用
於赵勰,汪瑶,李亚楠,沈峰,王彦春..血管内皮生长因子C参与脑膜淋巴管介导β淀粉样蛋白清除的研究进展[J].浙江大学学报（医学版）,2026,55(5):383-390,8.基金项目
国家自然科学基金(82405575) （82405575）
湖北省自然科学基金(2023AFD113,2024AFD298) （2023AFD113,2024AFD298）
湖北省中医药管理局科研项目(ZY2023F138) （ZY2023F138）
湖北省中医药重点学科(针灸学)创新项目(XK202405) （针灸学）
湖北中医药大学2025年度博士研究生创新能力提升计划(2025BSCX05)This study was supported by National Natural Science Foundation of China(82405575),Hubei Provincial Natural Science Foundation of China(2023AFD113,2024AFD298),Scientific Research Project of the Hubei Admini-stration of Traditional Chinese Medicine(ZY2023F138),Innova-tion Project of the Key Discipline of Traditional Chinese Medicine(Acupuncture and Moxibustion)in Hubei Province(XK202405),and 2025 Innovation Ability Program for Doctoral Students of Hubei University of Chinese Medicine(2025BSCX05) （2025BSCX05）
