肿瘤防治研究2026，Vol.53Issue(7)：556-560,5.DOI:10.3971/j.issn.1000-8578.2026.25.0934
金纳米颗粒辅助超声疗法重塑三阴性乳腺癌免疫微环境的研究进展
Advances in Nanoparticle-Assisted Ultrasound Therapy for Remodeling Immune Microenvironment in Triple-Negative Breast Cancer
摘要
Abstract
Nanoparticle-assisted ultrasound therapy(NAUT)employs low-frequency ultrasound to in situ activate gold nanoparticles,generating cavitation-and sonodynamic-derived reactive oxygen species that elicit immunogenic cell death and convert the immunologically"cold"triple-negative breast cancer(TNBC)microenvironment into a"hot"phenotype.Benefiting from its physical targeting precision,minimal invasiveness,and potent immuno-sensitization,NAUT surpasses conventional chemotherapy or single-agent immune checkpoint inhibitors in overcoming TNBC heterogeneity and eradicating minimal residual disease.In this review,the mechanistic advances of NAUT are summarized,the design of smart nanoplatforms is highlighted,its synergistic efficacy with immune checkpoint inhibitors is evaluated,and the clinical potential and challenges of NAUT in eradicating minimal residual disease are discussed.This review offers a new paradigm for precision physical-immunotherapy of TNBC.关键词
三阴性乳腺癌/金纳米颗粒/超声/免疫原性细胞死亡/肿瘤微环境Key words
Triple-negative breast cancer/Gold nanoparticles/Ultrasound/Immunogenic cell death/Tumor microenvironment分类
医药卫生引用本文复制引用
张典,王宁,高兴春,KIEW Lik Voon..金纳米颗粒辅助超声疗法重塑三阴性乳腺癌免疫微环境的研究进展[J].肿瘤防治研究,2026,53(7):556-560,5.基金项目
国家自然科学基金面上项目(11971281) （11971281）
陕西省教育厅课题(22JS037,23JS049) （22JS037,23JS049）
陕西省科技厅课题(S2025-JC-QN-1895) （S2025-JC-QN-1895）
西安医学院校级课题(2023BS44,2024NLTS045,2024NLTS038,S202411840074,2024BS04)National Natural Science Foundation of China(No.11971281) （2023BS44,2024NLTS045,2024NLTS038,S202411840074,2024BS04）
Projects of Shaanxi Provincial Dep-artment of Education(Nos.22JS037,23JS049) （Nos.22JS037,23JS049）
Project of Shaanxi Provincial Department of Science and Tec-hnology(No.S2025-JC-QN-1895) （No.S2025-JC-QN-1895）
University-level Projects of Xi'an Medical University(Nos.2023BS44,2024NLTS045,2024NLTS038,S202411840074,2024BS04) （Nos.2023BS44,2024NLTS045,2024NLTS038,S202411840074,2024BS04）
