中医儿科杂志2026，Vol.22Issue(4)：43-47,5.DOI:10.16840/j.issn1673-4297.2026.04.10
栝蒌桂枝汤联合西药治疗小儿癫痫痰气郁滞证42例临床观察
Clinical Observation on 42 Cases of Pediatric Epilepsy with Phlegm-Qi Stagnation Pattern Treated with Gualou Guizhi Tang(栝蒌桂枝汤)Combined with Western Medicine
摘要
Abstract
Objective To observe the clinical efficacy of Gualou Guizhi Tang(栝蒌桂枝汤)combined with Western medicine in the treatment of pediatric epilepsy with phlegm-qi stagnation syndrome.Methods A total of 84 children with epilepsy admitted to the Department of Pediatrics of Shangyu People's Hospital of Sha-oxing from June 2022 to June 2024 were collected and randomly divided into a treatment group and a control group using a random number table method,with 42 cases in each group.The control group was treated with low-dose topiramate and oxcarbazepine.The treatment group received Gualou Guizhi Tang in addition to the treatment given to the control group.One month constituted one course of treatment for both groups.After three courses of treatment,the following parameters were recorded for both groups:seizure status(seizure frequency and seizure duration),neurological function(sympathetic skin response),serum neurofactor levels[neuron-specific enolase(NSE),central nervous system specific protein(S-100β protein),brain-derived neurotrophic factor(BDNF)],and clinical efficacy.Results Before treatment,there were no statistically significant differ-ences in seizure frequency and seizure duration between the two groups(P＞0.05),indicating comparability.Af-ter treatment,seizure frequency and seizure duration were significantly reduced in both groups compared with those before treatment in the same group(P＜0.05),and the reduction was more significant in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in the latency and ampli-tude of sympathetic skin response between the two groups(P＞0.05),indicating comparability.After treatment,the latency of sympathetic skin response was shortened and the amplitude was increased in both groups com-pared with those before treatment in the same group(P＜0.05),and the changes were more significant in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in serum levels of NSE,S-100β protein,and BDNF between the two groups(P＞0.05),indicating comparability.After treat-ment,serum levels of NSE and S-100β protein were significantly decreased,while BDNF levels were signifi-cantly increased in both groups compared with those before treatment in the same group(P＜0.05),and the changes were more significant in the treatment group(P＜0.05).The total effective rate was 73.81％(31/42)in the control group and 90.48％(38/42)in the treatment group,and the difference between the two groups was statistically significant(P＜0.05).Conclusion Gualou Guizhi Tang combined with Western medicine in the treatment of pediatric epilepsy of phlegm-qi stagnation pattern can effectively reduce seizure frequency and sei-zure duration,improve neurological function,and regulate serum neurofactor levels.The efficacy is signifi-cant,and this combination is worthy of clinical promotion and application.关键词
小儿癫痫/痰气郁滞证/栝蒌桂枝汤/神经功能/血清神经因子/临床观察Key words
pediatric epilepsy/phlegm-qi stagnation syndrome/Gualou Guizhi Tang(栝蒌桂枝汤)/neu-rological function/serum neurofactors/clinical observation分类
医药卫生引用本文复制引用
杜文燕,王玲芝,童一川,顾金爱,王志良,董娇英..栝蒌桂枝汤联合西药治疗小儿癫痫痰气郁滞证42例临床观察[J].中医儿科杂志,2026,22(4):43-47,5.基金项目
浙江省中医药科技计划项目(2024037550). （2024037550）
