中医眼耳鼻喉杂志2026，Vol.16Issue(3)：167-171,5.DOI:10.3969/j.issn.1674-9006.2026.03.009
近视发生发展中视网膜分子信号通路的调控机制及干预研究进展
Research progress on the regulatory mechanism and intervention of molecular signaling pathways in the retina during the oc-currence and development of myopia
摘要
Abstract
Myopia has emerged as a significant global public health challenge,characterized by a complex pathogen-esis involving intricate interactions among multiple signaling pathways.As the primary site for visual signal perception and transduction,the retina plays a central role in initiating the myopic cascade.It detects changes in the visual environment,activates downstream molecular signaling pathways,and regulates cellular processes such as proliferation,apoptosis,extra-cellular matrix metabolism,and inflammatory responses.Through the retina-choroid-sclera signaling axis,the retina medi-ates scleral remodeling,thereby inducing abnormal elongation of the eye axis and promoting the occurrence and progression of myopia.This review systematically outlines the regulatory mechanisms of key signaling pathways—including dopamine,Wnt/β-catenin,ON/OFF,MAPK/ERK,TGF-β/Smad,and inflammation-related pathways—in myopia development.It fur-ther elucidates the role of epigenetic regulation in retinal signaling and summarizes intervention strategies based on retinal pathways,such as pharmacological,genetic,optical environment modulation,and cell-based therapies.This synthesis pro-vides a theoretical foundation and research directions for further understanding retinal mechanisms in myopia pathogene-sis,identifying molecular targets,and developing targeted precision interventions.关键词
近视/视网膜/信号通路/表观遗传/干预策略Key words
Myopia/Retina/Signaling pathway/Epigenetics/Intervention strategy分类
医药卫生引用本文复制引用
郭皓雪,刘美宋,刘一澄,蒋文清,曾洁萍..近视发生发展中视网膜分子信号通路的调控机制及干预研究进展[J].中医眼耳鼻喉杂志,2026,16(3):167-171,5.基金项目
国家自然科学基金委员会面上项目(编号:81973911) （编号:81973911）
