中药与临床2026，Vol.17Issue(4)：8-14,7.
花椒养生汤提取工艺优化研究
Optimization of the extraction of Huajiao Yangsheng decoction
摘要
Abstract
Objective:To systematically analyze the chemical constituents of Huajiao Yangsheng decoction(YST)and opti-mize its extraction of the YST.Methods:UPLC-Q-Orbitrap HRMS was used to identify the chemical constituents of YST.HPLC was used to establish quality control method using the reference agents of ginsenosides Rg1,Rb1,Re,cinnamaldehyde,gingerol,and hydroxy-α-sanshool(HAS).The weighted comprehensive score regarding the above-mentioned reference agents in YST was used as index,and then orthogonal design was used to optimize the YST extraction with the ethanol content,soaking time,extrac-tion time,extraction frequency.Results:A total of 48 compounds were identified from YST,including ginsenoside Re,6-gingerol,etc.The optimal extraction parameters for YST based on orthogonal design was decided as:soaking for 2 h,8 times 70％alcohol for reflux extraction 3 times,and each time lasting for 1.5 h.Conclusion:This study identifies chemical composition profile of YST,establishes its quality standards,and optimizes its extraction,laying the foundation for its clinical application and modern dosage form development.关键词
花椒养生汤/正交试验/工艺优化/成分分析Key words
Huajiao Yangsheng decoction/orthogonal experiment/extraction process optimization/constituents analysis分类
医药卫生引用本文复制引用
陈丽萍,叶楠,彭伟,艾莉,杨丹,刘君..花椒养生汤提取工艺优化研究[J].中药与临床,2026,17(4):8-14,7.基金项目
四川中医药大健康产业发展与乡村振兴研究中心项目(DJKYB202306) （DJKYB202306）
