中药与临床2026，Vol.17Issue(4)：24-28,5.
颅复丸对小鼠的急性毒性研究
Acute toxicity study of Lufu Pills in mice
摘要
Abstract
Objective:To investigate the acute toxicity of Lufu Pills(LFP)in Kunming(KM)mice.Methods:Forty-eight KM mice were randomly divided into three groups:a blank control group and high-and low-dose LFP groups.The control group received normal saline,whereas the treatment groups received LFP at 13.2 and 6.6 g·kg-1,respectively,via gavage.All animals were observed for 14 consecutive days,during which general condition,body weight and behavioral changes were recorded.At the end of the observation period,serum samples were collected for routine biochemical analyses.The mice were then necropsied.Liver,heart,spleen,lung and kidney were examined macroscopically,weighed to calculate organ coefficients,and processed for histopathological evaluation.Results:No deaths or overt signs of toxicity occurred in any group.No significant differences were observed among groups in body weight,organ coefficients,or histopathological findings.Although biochemical parameters such as ALT(alanine aminotransferase),TP(total protein),ALB(albumin),TG(triglycerides),and UREA(urea nitrogen)showed vari-able elevations,these changes lacked a clear dose-dependent relationship.Conclusion:Within the dose range of 13.2 g·kg-1,intra-gastric administration of LFP did not cause significant pathological damage to the major organs of KM mice.However,it is neces-sary to monitor its impact on liver and kidney functions during the medication process.This study can provide a reference for clini-cal medication.关键词
颅复丸/急性毒性研究/用药安全/颅内肿瘤Key words
Lufu Pills/acute toxicity study/medication safety/intracranial tumor分类
医药卫生引用本文复制引用
余蕾,彭成,王波涛,伏铠文,冷静,邱敏,辇伟奇..颅复丸对小鼠的急性毒性研究[J].中药与临床,2026,17(4):24-28,5.基金项目
重庆市中医院科研立项项目(2024YZZKY004) （2024YZZKY004）
重庆市医学领军人才项目(YXLJ2401) （YXLJ2401）
重庆市卫生健康委中医药科研项目(2025ZYZD002) （2025ZYZD002）
重庆英才包干制项目(cstc2024ycjh-bgzxm0163) （cstc2024ycjh-bgzxm0163）
