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Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration

Yuan Xie Binming Han Xin Tao Fangjun Song Cheng Zhao Eric Delpire Jingyuan Li Shan Wu Jiangtao Guo

Biophysics Reports2026，Vol.12Issue(3)：P.193-206,14.

Biophysics Reports2026，Vol.12Issue(3)：P.193-206,14.DOI:10.52601/bpr.2025.240057

Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration

Yuan Xie ¹Binming Han ²Xin Tao ³Fangjun Song ⁴Cheng Zhao ⁴Eric Delpire ⁵Jingyuan Li ²Shan Wu ³Jiangtao Guo⁶

作者信息

1. Department of Neurosurgery,Xijing Hospital,Fourth Military Medical University,Xi''an 710032,China
2. School of Physics,Zhejiang University,Hangzhou 310058,China
3. State Key Laboratory of Biocatalysis and Enzyme Engineering,Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources,Hubei Key Laboratory of Industrial Biotechnology,School of Life Sciences,Hubei University,Wuhan 430062,China
4. Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China
5. Department of Anesthesiology,Vanderbilt University School of Medicine,Nashville,TN 37232,USA
6. Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China Nanhu Brain-Computer Interface Institute,Hangzhou 311100,China NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Science and Brain-machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310058,China State Key Laboratory of Plant Environmental Resilience,College of Life Sciences,Zhejiang University,Hangzhou 310058,China Cancer Center,Zhejiang University,Hangzhou 310058,China
折叠

摘要

关键词

KCC4/Cryo-EM titration/Ions selectivity/Molecular dynamic simulation/Ions cotransport

分类

生物科学

引用本文复制引用

Yuan Xie,Binming Han,Xin Tao,Fangjun Song,Cheng Zhao,Eric Delpire,Jingyuan Li,Shan Wu,Jiangtao Guo..Structural basis for the ion selectivity of potassium-chloride cotransporter KCC4 revealed by cryo-EM titration[J].Biophysics Reports,2026,12(3):P.193-206,14.

基金项目

supported in part by the National Natural Science Foundation of China(32200803 to Y.X.,32371204 to J.G.,32471319 to S.W.,and 11722434 and 11874319 to J.L.) （32200803 to Y.X.,32371204 to J.G.,32471319 to S.W.,and 11722434 and 11874319 to J.L.）

the Ministry of Science and Technology(2020YFA0908501 to J.G.) （2020YFA0908501 to J.G.）

the Fundamental Research Funds for the Central Universities(2021FZZX001-28 and 2025ZFJH01-01 to J.G.) （2021FZZX001-28 and 2025ZFJH01-01 to J.G.）

supported MOE Frontier Science Center for Brain Science&Brain-Machine Integration,Zhejiang University （）

the support of K.C.Wong Education Foundation （）

granted by the A-level Doctoral Research Foundation from Xijing Hospital,Fourth Military Medical University(XJARC05) （XJARC05）

by Special Project of A-level Doctoral Talent Support Program from Xijing Hospital,Fourth Military Medical University(AL202406) （AL202406）

supported by the Distinguished Young Scholars of Hubei Province(2022CFA078) （2022CFA078）

the Knowledge Innovation Program of the Wuhan-Shugung Project(2023020201020418) （2023020201020418）

the National Key Research and Development Program of China(2020YFA0908400)。（2020YFA0908400）

Biophysics Reports

ISSN：2364-3439

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