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Dose-dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Na Li Ziqing Jia Zhe Cong Jianrong Ma Jiahan Lu Yongzhi Hou Fei Wang Jiasen Yang Ting Chen Jingjing Zhang Dong Zhang Jing Xue

Animal Models and Experimental Medicine2026，Vol.9Issue(5)：P.1047-1055,9.

Animal Models and Experimental Medicine2026，Vol.9Issue(5)：P.1047-1055,9.DOI:10.1002/ame2.70227

Dose-dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Na Li ¹Ziqing Jia ¹Zhe Cong ¹Jianrong Ma ¹Jiahan Lu ¹Yongzhi Hou ¹Fei Wang ¹Jiasen Yang ¹Ting Chen ¹Jingjing Zhang ¹Dong Zhang ¹Jing Xue²

作者信息

1. NHC Key Laboratory of Human Disease Comparative Medicine,National Center of Technology Innovation for Animal Model,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,China
2. NHC Key Laboratory of Human Disease Comparative Medicine,National Center of Technology Innovation for Animal Model,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,China State Key Laboratory of Respiratory Health and Multimorbidity,Key Laboratory of Pathogen Infection Prevention and Control,Institute of Laboratory Animal Science,Ministry of Education,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,China
折叠

摘要

关键词

inflammatory response/lethal model/mpox virus/NPG(NOD.Cg-Prkdc^(scid)Il2rg^(tm1)/Vst)mice/viremia

分类

医药卫生

引用本文复制引用

Na Li,Ziqing Jia,Zhe Cong,Jianrong Ma,Jiahan Lu,Yongzhi Hou,Fei Wang,Jiasen Yang,Ting Chen,Jingjing Zhang,Dong Zhang,Jing Xue..Dose-dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus[J].Animal Models and Experimental Medicine,2026,9(5):P.1047-1055,9.

基金项目

National Key Research and Development Program of China,Grant/Award Number:2024YFC2309500 （）

Scientific Research Innovation Capability Support Project for Young Faculty,Grant/Award Number:SRICSPYF-ZY2025119 （）

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences,China,Grant/Award Number:2025-I2M-XHJC-032 and 2025-I2M-KJ-021 （）

Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project,Grant/Award Number:2025ZD01904300。（）

Animal Models and Experimental Medicine

ISSN：2096-5451

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