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Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia:Implications for sepsis susceptibility in immunocompromised hosts

Thansita Bhunyakarnjanarat Chatsuree Suksamai Dhammika Leshan Wannigama Kent Doi Wiwat Chancharoenthana Asada Leelahavanichkul

Animal Models and Experimental Medicine2026，Vol.9Issue(5)：P.967-979,13.

Animal Models and Experimental Medicine2026，Vol.9Issue(5)：P.967-979,13.DOI:10.1002/ame2.70218

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia:Implications for sepsis susceptibility in immunocompromised hosts

Thansita Bhunyakarnjanarat ¹Chatsuree Suksamai ¹Dhammika Leshan Wannigama ²Kent Doi ³Wiwat Chancharoenthana ⁴Asada Leelahavanichkul⁵

作者信息

1. Department of Microbiology,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand Faculty of Medicine,Center of Excellence on Translational Research in Inflammation and Immunology(CETRII),Chulalongkorn University,Bangkok,Thailand
2. Department of Infectious Diseases,Faculty of Medicine Yamagata University and Yamagata University Hospital,Yamagata,Japan Department of Infectious Diseases and Infection Control,Yamagata Prefectural Central Hospital,Yamagata,Japan Pathogen Hunter''s Research Collaborative Team,Yamagata Prefectural Central Hospital,Yamagata,Japan Yamagata Prefectural University of Health Sciences,Yamagata,Japan Biofilms and Antimicrobial Resistance Consortium of ODA Receiving Countries,The University of Sheffield,Sheffield,UK
3. Emergency and Critical Care Medicine,The University of Tokyo Hospital,Tokyo,Japan
4. Department of Clinical Tropical Medicine,Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand Tropical Immunology and Translational Research Unit(TITRU),Faculty of Tropical Medicine,Mahidol University,Bangkok,Thailand
5. Department of Microbiology,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand Faculty of Medicine,Center of Excellence on Translational Research in Inflammation and Immunology(CETRII),Chulalongkorn University,Bangkok,Thailand Division of Nephrology,Department of Medicine,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand
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摘要

关键词

alcohol/endotoxemia/gut barrier dysfunction/gut microbiota/sepsis susceptibility

分类

医药卫生

引用本文复制引用

Thansita Bhunyakarnjanarat,Chatsuree Suksamai,Dhammika Leshan Wannigama,Kent Doi,Wiwat Chancharoenthana,Asada Leelahavanichkul..Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia:Implications for sepsis susceptibility in immunocompromised hosts[J].Animal Models and Experimental Medicine,2026,9(5):P.967-979,13.

基金项目

Mahidol University Strategic Research Fund:fiscal year 2023,Grant/Award Number:MU-SRF-PF-03A/66。（）

Animal Models and Experimental Medicine

ISSN：2096-5451

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