首页|期刊导航|International Journal of Oral Science|Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux

Nan Ni Moxu Wang Zhiran Yuan Leqi Zhang Jilin Cai Qingqing Du Pengcheng Li Chang Gao Hanwen Zhang Yuancheng Li Hua Yuan

International Journal of Oral Science2026，Vol.18Issue(3)：P.459-473,15.

International Journal of Oral Science2026，Vol.18Issue(3)：P.459-473,15.DOI:10.1038/s41368-025-00402-7

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux

Nan Ni ¹Moxu Wang ¹Zhiran Yuan ²Leqi Zhang ¹Jilin Cai ¹Qingqing Du ¹Pengcheng Li ¹Chang Gao ¹Hanwen Zhang ¹Yuancheng Li ³Hua Yuan⁴

作者信息

1. Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing,China Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing,China
2. Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing,China Department of Oral and Dental Implantology,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing,China
3. Central Research Laboratory,Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Institute of Dermatology,Chinese Academy of Medicine Sciences and Peking Union Medical College,Nanjing,China
4. Jiangsu Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing,China Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Stomatology,Nanjing Medical University,Nanjing,China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing,China Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University,Nanjing,China
折叠

摘要

关键词

oral epithelial tissue sam/splicing quantitative trait loci/antisense oligonucleotide/oral squamous cell carcinoma oscc development/expression quantitative trait loci/oral squamous cell carcinoma/splice quantitative trait loci sqtl serve/rna sequencing data

分类

医药卫生

引用本文复制引用

Nan Ni,Moxu Wang,Zhiran Yuan,Leqi Zhang,Jilin Cai,Qingqing Du,Pengcheng Li,Chang Gao,Hanwen Zhang,Yuancheng Li,Hua Yuan..Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux[J].International Journal of Oral Science,2026,18(3):P.459-473,15.

基金项目

supported by funding from the National Natural Science Foundation of China(81672678) （81672678）

the Key Project of Health Commission of Jiangsu Province(ZDB202001) （ZDB202001）

the Project of Health Commission of Jiangsu Province(H2019034) （H2019034）

the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD,2018-87)。（PAPD,2018-87）

International Journal of Oral Science

ISSN：1674-2818

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