International Journal of Oral Science2026，Vol.18Issue(3)：P.357-373,17.DOI:10.1038/s41368-026-00429-4
Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration
Anjali P.Patni 1Rubul Mout 2Ammar Alghadeer 3Rachel H.Moore 4Samera Nademi 5Brandon J.Ausk 6Philippe Huber 6Riya Keshri 7Mary Regier 8Robert A.Cornell 9Ted Gross 6Benjamin S.Freedman 10George Q.Daley 2David Baker 11Julie Mathieu 12Hannele Ruohola-Baker1
作者信息
- 1. Department of Oral Health Sciences,University of Washington,School of Dentistry,Seattle,WA,USA Department of Biochemistry,University of Washington,School of Medicine,Seattle,WA,USA Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA
- 2. Stem Cell&Regenerative Biology Program,Boston Children’s Hospital,Boston,MA,USA Department of Biological Chemistry and Molecular Pharmacology,Blavatnik Institute,Harvard Medical School,Boston,MA,USA Harvard Stem Cell Institute,Harvard University,Cambridge,MA,USA
- 3. Department of Biomedical Dental Sciences,College of Dentistry,Imam Abdulrahman Bin Faisal University,Dammam,Saudi Arabia
- 4. Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA Department of Comparative Medicine,University of Washington,School of Medicine,Seattle,WA,USA
- 5. Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA Department of Medicine,Division of Nephrology,Kidney Research Institute and Institute for Stem Cell and Regenerative Medicine,Seattle,WA,USA
- 6. Department of Orthopaedic Surgery and Sports Medicine University of Washington Seattle,Seattle,WA,USA
- 7. Department of Biochemistry,University of Washington,School of Medicine,Seattle,WA,USA Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA
- 8. Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA
- 9. Department of Oral Health Sciences,University of Washington,School of Dentistry,Seattle,WA,USA Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA
- 10. Department of Medicine,Division of Nephrology,Kidney Research Institute and Institute for Stem Cell and Regenerative Medicine,Seattle,WA,USA
- 11. Department of Biochemistry,University of Washington,School of Medicine,Seattle,WA,USA Institute for Protein Design,University of Washington,Seattle,WA,USA Howard Hughes Medical Institute,University of Washington,Seattle,WA,USA
- 12. Department of Biochemistry,University of Washington,School of Medicine,Seattle,WA,USA Institute for Stem Cell and Regenerative Medicine,University of Washington,School of Medicine,Seattle,WA,USA Department of Comparative Medicine,University of Washington,School of Medicine,Seattle,WA,USA
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摘要
关键词
ameloblast maturation/tooth regeneration/regenerative dentistrytodayit/mineralized material/soluble notch agonist/notch receptor/iam organoid/enamel tissue formation分类
医药卫生引用本文复制引用
Anjali P.Patni,Rubul Mout,Ammar Alghadeer,Rachel H.Moore,Samera Nademi,Brandon J.Ausk,Philippe Huber,Riya Keshri,Mary Regier,Robert A.Cornell,Ted Gross,Benjamin S.Freedman,George Q.Daley,David Baker,Julie Mathieu,Hannele Ruohola-Baker..Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration[J].International Journal of Oral Science,2026,18(3):P.357-373,17.基金项目
supported by ISCRM Fellows Program(Anjali Patni) （Anjali Patni）
grants from the National Institutes of Health DE033016(J.M.,R.A.C.and H.R-B.),1P01GM081619,R01GM097372,R01GM083867 （J.M.,R.A.C.and H.R-B.）
NHLBI Progenitor Cell Biology Consortium(U01HL099997 （）
UO1HL099993)SCGE COF220919(H.R-B) （H.R-B）
Molecule(J.M.and H.R-B.) （J.M.and H.R-B.）
AHA 19IPLOI34760143 （）
Brotman Baty Institute(BBI) （BBI）
DOD PR203328 W81XWH-21-1-0006 （）
Stem Cell Gift Funds for H.R-B。 （）
