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Non-canonical role of“S6K1–SGK1”pathway in neuronal necroptosis following traumatic brain injury

Shuchao Wang Yating Tan Minghai Hu Meijuan Wang Lu Liang Xing Luo Dan Chen Bing Jiang Ceshi Chen Jufang Huang Kun Xiong

Genes & Diseases2026,Vol.13Issue(4):P.706-722,17.
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Genes & Diseases2026,Vol.13Issue(4):P.706-722,17.DOI:10.1016/j.gendis.2025.101876

Non-canonical role of“S6K1–SGK1”pathway in neuronal necroptosis following traumatic brain injury

Shuchao Wang 1Yating Tan 2Minghai Hu 3Meijuan Wang 4Lu Liang 5Xing Luo 6Dan Chen 7Bing Jiang 8Ceshi Chen 9Jufang Huang 10Kun Xiong7

作者信息

  • 1. Department of Ophthalmology,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China Center for Medical Research,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China National Clinical Research Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China National Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China
  • 2. Center for Medical Research,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China Department of Anatomy and Neurobiology,Xiangya School of Basic Medical Sciences,Central SouthUniversity,Changsha,Hunan 410013,China
  • 3. Department of Anatomy and Neurobiology,Xiangya School of Basic Medical Sciences,Central SouthUniversity,Changsha,Hunan 410013,China
  • 4. Medical Imaging Center,Qingdao West Coast New District People’s Hospital,Qingdao,Shandong 266100,China
  • 5. Department of Ophthalmology,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China Center for Medical Research,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China
  • 6. Center for Medical Research,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China
  • 7. Department of Anatomy and Neurobiology,Xiangya School of Basic Medical Sciences,Central SouthUniversity,Changsha,Hunan 410013,China Hunan Key Laboratory of Ophthalmology,Changsha,Hunan 410011,China
  • 8. Hunan Clinical Research Center of Ophthalmic Disease,Changsha,Hunan 410011,China National Clinical Research Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China National Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China
  • 9. Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China Academy of Biomedical Engineering,Kunming Medical University,Kunming,Yunnan 650500,China The Third Affiliated Hospital,Kunming Medical University,Kunming,Yunnan 650118,China
  • 10. Department of Anatomy and Neurobiology,Xiangya School of Basic Medical Sciences,Central SouthUniversity,Changsha,Hunan 410013,China Hunan Key Laboratory of Ophthalmology,Changsha,Hunan 410011,China Department of Radiology,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China National Clinical Research Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China National Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China
  • 折叠

摘要

关键词

mTOR/Necroptosis/Oxidative stress/S6K1/SGK1/Traumatic braininjury

分类

医药卫生

引用本文复制引用

Shuchao Wang,Yating Tan,Minghai Hu,Meijuan Wang,Lu Liang,Xing Luo,Dan Chen,Bing Jiang,Ceshi Chen,Jufang Huang,Kun Xiong..Non-canonical role of“S6K1–SGK1”pathway in neuronal necroptosis following traumatic brain injury[J].Genes & Diseases,2026,13(4):P.706-722,17.

基金项目

supported by the National Natural Science Foundation of China(No.82101126,82572869,82172196,82372507,81371011,81671225) (No.82101126,82572869,82172196,82372507,81371011,81671225)

the Natural Science Foundation of Hunan Province,China(No.2024JJ5472,2021JJ40873) (No.2024JJ5472,2021JJ40873)

the Scientific Research Launch Project fornew employees of the Second Xiangya Hospital of Central South University(China) (China)

the Flexible Talent Introduction Program of Central South University(China). (China)

Genes & Diseases

2352-4820

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