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Suppression of UCP2 alleviatesleukemogenesis by enhancingbranched-chain amino acids-inducedoxidative stress via activating the PI3K/AKT/mTOR signaling pathway

Agida Okohi Innocent Yajie Shen Yixuan Gao Ruixin Sun Kasimujiang aximujiang Zizhen Xu Jinke Cheng Jiao Ma

Genes & Diseases2026，Vol.13Issue(4)：P.521-537,17.

Genes & Diseases2026，Vol.13Issue(4)：P.521-537,17.DOI:10.1016/j.gendis.2025.101794

Suppression of UCP2 alleviatesleukemogenesis by enhancingbranched-chain amino acids-inducedoxidative stress via activating the PI3K/AKT/mTOR signaling pathway

Agida Okohi Innocent ¹Yajie Shen ²Yixuan Gao ¹Ruixin Sun ³Kasimujiang aximujiang ⁴Zizhen Xu ⁵Jinke Cheng ¹Jiao Ma¹

作者信息

1. Department of Biochemistry and Molecular Cell Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
2. State Key Laboratory of Genetic Engineering,School of Life Sciences and Huashan Hospital,Shanghai Engineering Research Center of Industrial Microorganisms,Fudan University,Shanghai 200438,China
3. Department of Biochemistry and Molecular Cell Biology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Department of Laboratory Medicine,College of Health Science and Technology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
4. Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xinjiang Medical University,Urumqi,Xinjiang 710061,China
5. Department of Laboratory Medicine,College of Health Science and Technology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
折叠

摘要

关键词

AML branched-chainamino acids/Leukemogenesis/Oxidative stress/PI3K/AKT/mTORsignaling/UCP2

分类

医药卫生

引用本文复制引用

Agida Okohi Innocent,Yajie Shen,Yixuan Gao,Ruixin Sun,Kasimujiang aximujiang,Zizhen Xu,Jinke Cheng,Jiao Ma..Suppression of UCP2 alleviatesleukemogenesis by enhancingbranched-chain amino acids-inducedoxidative stress via activating the PI3K/AKT/mTOR signaling pathway[J].Genes & Diseases,2026,13(4):P.521-537,17.

基金项目

supported by the Natural Science Foundation of Shanghai,China(No.23ZR1436100) （No.23ZR1436100）

the National Key R&D Program of China(No.2020TFA0803603) （No.2020TFA0803603）

the National Natural Science Foundation of China(No.82370186,82030075,82230049). （No.82370186,82030075,82230049）

Genes & Diseases

ISSN：2352-4820

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