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Oenothera biennis water extract inhibits the NLRP3 infl ammasome by activating microglial autophagy via the AMPK-PI3K/AKT/mTOR pathway in Alzheimer’s disease

Li Zhang Lan Deng Xiaogang Zhou Dongsheng Fan Jianming Wu Chi Feng Nan Jiang Liwen Wei Dalian Qin Fang Ren Lu Yu Anguo Wu

Food Science and Human Wellness2026，Vol.15Issue(6)：P.2708-2728,21.

Food Science and Human Wellness2026，Vol.15Issue(6)：P.2708-2728,21.DOI:10.26599/FSHW.2025.9250595

Oenothera biennis water extract inhibits the NLRP3 infl ammasome by activating microglial autophagy via the AMPK-PI3K/AKT/mTOR pathway in Alzheimer’s disease

Li Zhang ¹Lan Deng ²Xiaogang Zhou ²Dongsheng Fan ³Jianming Wu ²Chi Feng ²Nan Jiang ²Liwen Wei ²Dalian Qin ²Fang Ren ⁴Lu Yu ²Anguo Wu⁵

作者信息

1. Department of Pharmacy,Neijiang Hospital of Traditional Chinese Medicine,Neijiang 641000,China
2. Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation,Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica,Key Laboratory of Medical Electrophysiology of Ministry of Education,School of Pharmacy,Southwest Medical University,Luzhou 646000,China
3. Department of Pharmacy,The First Affi liated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550005,China
4. Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China
5. Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation,Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica,Key Laboratory of Medical Electrophysiology of Ministry of Education,School of Pharmacy,Southwest Medical University,Luzhou 646000,China Institute of Traditional Chinese Medicine Health Industry,China Academy of Chinese Medical Sciences,Nanchang 330038,China
折叠

摘要

关键词

Alzheimer’s disease/Oenothera biennis/NLRP3 infl ammasome/Autophagy/AMPK-PI3K/AKT/mTOR/Caenorhabditis elegans/3xTg-AD mice

分类

医药卫生

引用本文复制引用

Li Zhang,Lan Deng,Xiaogang Zhou,Dongsheng Fan,Jianming Wu,Chi Feng,Nan Jiang,Liwen Wei,Dalian Qin,Fang Ren,Lu Yu,Anguo Wu..Oenothera biennis water extract inhibits the NLRP3 infl ammasome by activating microglial autophagy via the AMPK-PI3K/AKT/mTOR pathway in Alzheimer’s disease[J].Food Science and Human Wellness,2026,15(6):P.2708-2728,21.

基金项目

supported by the National Natural Science Foundation of China(81903829) （81903829）

the Open Project from the State Key Laboratory of Traditional Chinese Medicine Syndrome(SKLKY2024B0006) （SKLKY2024B0006）

the Foundation of Institute of Traditional Chinese Medicine Health Industry,China Academy of Chinese Medical Sciences(ZYTS-2025011) （ZYTS-2025011）

Ziyang Central Hospital-Southwest Medical University Science and Technology Strategic Cooperation(2025ZYXNYD13) （2025ZYXNYD13）

the Open Fund of Innovation Center for Basic Research on Metabolic Cardiovascular Diseases,Southwest Medical University(xnykdxcxzx-2025-10) （xnykdxcxzx-2025-10）

the Joint Project of Luzhou Municipal People’s Government and Southwest Medical University(2024LZXNYDJ026) （2024LZXNYDJ026）

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Food Science and Human Wellness

ISSN：2097-0765

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