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Therapeutic efficacy of Jichuan decoction(济川煎)in slow-transit constipation:focus on gut microbiota modulation

WANG Xiumin LÜ Lixia LI Jianghua CHEN Jilan TAN Cailin DING Weijun

Journal of Traditional Chinese Medicine2026，Vol.46Issue(3)：P.544-551,8.

Journal of Traditional Chinese Medicine2026，Vol.46Issue(3)：P.544-551,8.DOI:10.19852/j.cnki.jtcm.2026.03.002

Therapeutic efficacy of Jichuan decoction(济川煎)in slow-transit constipation:focus on gut microbiota modulation

WANG Xiumin ¹LÜ Lixia ²LI Jianghua ³CHEN Jilan ⁴TAN Cailin ⁵DING Weijun⁴

作者信息

1. Department of General Surgery,Chengdu Second People''s Hospital,Chengdu 610021,China Department of Anorectal Medicine,Affiliated Hospital of Integrative Chinese Medicine and Western Medicine of Chengdu University of Traditional Chinese Medicine,Chengdu 610042,China Department of Fundamental Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China
2. Department of Endocrinology and Metabolism,Chengdu First People’s Hospital,Chengdu 610041,China
3. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,School of Pharmacy,Chengdu University,Chengdu 610106,China
4. Department of Fundamental Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China
5. Department of Gastroenterology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Deyang Hospital,Deyang 618000,China
折叠

摘要

关键词

slow-transit constipation/enteric nervous system/intestinal microbiota/Akkermansia muciniphila/Jichuan decoction

分类

医药卫生

引用本文复制引用

WANG Xiumin,LÜ Lixia,LI Jianghua,CHEN Jilan,TAN Cailin,DING Weijun..Therapeutic efficacy of Jichuan decoction(济川煎)in slow-transit constipation:focus on gut microbiota modulation[J].Journal of Traditional Chinese Medicine,2026,46(3):P.544-551,8.

基金项目

the National Natural Science Foundation of China:Exploring the Mechanism of Qi-tonifying and Phlegm-eliminating Acupuncture Promoting Intestinal Nerve Precursor Cell Regeneration in Obese Mice Based on the Single-cell RNA-sep Platform(No.82374176) （No.82374176）

the Natural Science Foundation of Sichuan Province:Discovery of"Active Center"Oligosaccharide Fragments in Polysaccharides of Pinellia Ternata and Its Processed Products and Research on Quality Evaluation Techniques and Methods(2022NSFSC0591) （2022NSFSC0591）

the Youth Nursery Project of Sichuan Provincial Health Commission:Mechanism Research on miR-491-5p Targeting Akt to Inhibit Intestinal Nerve Apoptosis in the Pathogenesis of Slow Transit Constipation(24QNMP030) （24QNMP030）

General Project of Sichuan Provincial Administration of Traditional Chinese Medicine:Exploring the Mechanism of Jichuan Decoction in Regulating Intestinal nerve Apoptosis in Slow Transit Constipation Rats Based on the Tumor Necrosis Factor Signaling Pathway(2024MS589) （2024MS589）

the Project of Sichuan Medical Association:Exploring the Mechanism of Jichuan Decoction in Regulating Intestinal Nerve Apoptosis in Slow Transit Constipation Rats Based on the Glial Cell line-derived Neurotrophic Factor/Phosphoinositide 3-kinase/Protein Kinase B Signaling Pathway(S23034)。（S23034）

Journal of Traditional Chinese Medicine

ISSN：0255-2922

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