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首页|期刊导航|The Journal of Biomedical Research|CYP3A triggers BDE47-induced ferritinophagy and ferroptosis in spermatogenic cells through ROS-mediated m6A regulation of ATG12

CYP3A triggers BDE47-induced ferritinophagy and ferroptosis in spermatogenic cells through ROS-mediated m6A regulation of ATG12

Shuyu Xu Wenxia Fan Jiangxue Qian Yuewen He Chunjin Li Chao Chen Li Wang Yongquan Yu Chao Wang Shoulin Wang

The Journal of Biomedical Research2026,Vol.40Issue(4):P.364-382,I0001-I0003,22.
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The Journal of Biomedical Research2026,Vol.40Issue(4):P.364-382,I0001-I0003,22.DOI:10.7555/JBR.40.20260159

CYP3A triggers BDE47-induced ferritinophagy and ferroptosis in spermatogenic cells through ROS-mediated m6A regulation of ATG12

Shuyu Xu 1Wenxia Fan 2Jiangxue Qian 2Yuewen He 1Chunjin Li 1Chao Chen 2Li Wang 2Yongquan Yu 2Chao Wang 2Shoulin Wang1

作者信息

  • 1. State Key Lab of Reproductive Medicine and Offspring Health,Institute of Toxicology,Nanjing Medical University,Nanjing,Jiangsu 211116,China Key Lab of Modern Toxicology of Ministry of Education,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211116,China
  • 2. Key Lab of Modern Toxicology of Ministry of Education,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211116,China
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摘要

关键词

cytochrome P4503A/2,2'',4,4''-tetrabromodiphenyl ether/reactive oxygen species/ferritinophagy/N6-methyladenosine/male reproductive damage

分类

医药卫生

引用本文复制引用

Shuyu Xu,Wenxia Fan,Jiangxue Qian,Yuewen He,Chunjin Li,Chao Chen,Li Wang,Yongquan Yu,Chao Wang,Shoulin Wang..CYP3A triggers BDE47-induced ferritinophagy and ferroptosis in spermatogenic cells through ROS-mediated m6A regulation of ATG12[J].The Journal of Biomedical Research,2026,40(4):P.364-382,I0001-I0003,22.

基金项目

supported by the National Natural Science Foundation of China(Grant Nos.82173562and 91743205 to S.W.,82273584 and 81903353 to C.W.) (Grant Nos.82173562and 91743205 to S.W.,82273584 and 81903353 to C.W.)

the key projects of Changzhou Medical Center of Nanjing Medical University(Grant No.CMCM202315 to S.W.) (Grant No.CMCM202315 to S.W.)

the Basic Research Program of Jiangsu Province(Grant No.BK20251854to C.W.)。 (Grant No.BK20251854to C.W.)

The Journal of Biomedical Research

1674-8301

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