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Targeting Aurora A Kinase Enhance the CDK4/6 Inhibitor Sensitivity in HR+/HER2-Breast Cancer

Juan Wu Yue Wang Honglin Yan Juanjuan Li Chuntao Quan Jingping Yuan Shengrong Sun

Oncology Research2026，Vol.34Issue(8)：P.544-565,22.

Oncology Research2026，Vol.34Issue(8)：P.544-565,22.DOI:10.32604/or.2026.081653

Targeting Aurora A Kinase Enhance the CDK4/6 Inhibitor Sensitivity in HR+/HER2-Breast Cancer

Juan Wu ¹Yue Wang ²Honglin Yan ³Juanjuan Li ⁴Chuntao Quan ⁵Jingping Yuan ³Shengrong Sun⁴

作者信息

1. Department of Pathology,Renmin Hospital of Wuhan University,Wuhan,China Department of Breast and Thyroid Surgery,Renmin Hospital of Wuhan University,Wuhan,China
2. Department of Oncology Medicine,Central People’s Hospital of Zhanjiang,Zhanjiang,China
3. Department of Pathology,Renmin Hospital of Wuhan University,Wuhan,China
4. Department of Breast and Thyroid Surgery,Renmin Hospital of Wuhan University,Wuhan,China
5. Department of Pathology,Biobank,Shenzhen Second People’s Hospital,Shenzhen University,Shenzhen,China
折叠

摘要

关键词

CDK4/6i resistance/spindle assembly checkpoint/Aurora A kinase/RB phosphorylation/ubiquitination

分类

医药卫生

引用本文复制引用

Juan Wu,Yue Wang,Honglin Yan,Juanjuan Li,Chuntao Quan,Jingping Yuan,Shengrong Sun..Targeting Aurora A Kinase Enhance the CDK4/6 Inhibitor Sensitivity in HR+/HER2-Breast Cancer[J].Oncology Research,2026,34(8):P.544-565,22.

基金项目

supported by the Shenzhen Medical Research Special Project(A2503080) （A2503080）

the Natural Science Foundation of Guangdong,China(No.2023A1515220238) （No.2023A1515220238）

the Natural Science Foundation of Shenzhen,China(JCYJ20230807115112024,JCYJ20250604180751067). （JCYJ20230807115112024,JCYJ20250604180751067）

Oncology Research

ISSN：0965-0407

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