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The SRC‑TOPK positive feedback loop promotes RB1 phosphorylation and drives the development of lung squamous cell carcinoma

Xiaofei Zeng Longzhen Cui Beibei Tang Fei Wang Hua He Feng Zhu Minjie Ma Chang Chen

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(5)：P.1144-1154,11.

Acta Biochimica et Biophysica Sinica2026，Vol.58Issue(5)：P.1144-1154,11.DOI:10.3724/abbs.2025149

The SRC‑TOPK positive feedback loop promotes RB1 phosphorylation and drives the development of lung squamous cell carcinoma

Xiaofei Zeng ¹Longzhen Cui ²Beibei Tang ²Fei Wang ³Hua He ⁴Feng Zhu ²Minjie Ma ⁴Chang Chen⁴

作者信息

1. The First School of Clinical Medicine,Lanzhou University,Lanzhou 730030,China Department of Thoracic Surgery,the First Hospital of Lanzhou University,Lanzhou 730030,China School of Clinical Medicine,Chengdu Medical College,Department of Cardiothoracic Surgery,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China
2. Translational Medicine Center,Huaihe Hospital of Henan University,Henan University,Kaifeng 475000,China
3. Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,China
4. The First School of Clinical Medicine,Lanzhou University,Lanzhou 730030,China Department of Thoracic Surgery,the First Hospital of Lanzhou University,Lanzhou 730030,China
折叠

摘要

关键词

lung squamous cell carcinoma/SRC/TOPK/targeted therapy

分类

医药卫生

引用本文复制引用

Xiaofei Zeng,Longzhen Cui,Beibei Tang,Fei Wang,Hua He,Feng Zhu,Minjie Ma,Chang Chen..The SRC‑TOPK positive feedback loop promotes RB1 phosphorylation and drives the development of lung squamous cell carcinoma[J].Acta Biochimica et Biophysica Sinica,2026,58(5):P.1144-1154,11.

基金项目

supported by the grants from the Research Initiation Fee for Henan University(No.S23015Y) （No.S23015Y）

the Key Research and Development Foundation of Gansu Province(No.24YFWA011) （No.24YFWA011）

the Joint Construction Project of Scientific and Technological Research and Development by Henan Provincial Health Commission(No.LHGJ20240399) （No.LHGJ20240399）

and the Natural Science Foundation of Gansu Province(No.23JRRA1597). （No.23JRRA1597）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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